PMID- 10610017
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20190915
IS  - 0277-0008 (Print)
IS  - 0277-0008 (Linking)
VI  - 19
IP  - 9
DP  - 1999 Sep
TI  - Intravenous immunoglobulin as adjunctive treatment for streptococcal toxic shock 
      syndrome associated with necrotizing fasciitis: case report and review.
PG  - 1094-8
AB  - Streptococcal toxic shock syndrome (STSS) is caused by infection with a 
      toxicogenic strain of Streptococcus pyogenes. Clinical manifestations may be 
      those of a mild illness, characterized by malaise, fever, and muscle pain, to 
      severe sepsis and multisystem organ failure. The syndrome may be associated with 
      several invasive infections including necrotizing fasciitis. Treatment is 
      primarily surgical debridement of infected tissue with supportive care, 
      antibiotics, and hemodynamic monitoring. Intravenous immunoglobulin (IVIG) is 
      reported to have beneficial effects in the management of STSS associated with 
      necrotizing fasciitis. The agent was successful in conjunction with surgical 
      excision and antibiotics in a patient with necrotizing fasciitis, toxic shock, 
      and multisystem organ failure. On the basis of this experience and a thorough 
      literature review, we concur that IVIG may be a useful adjunct in the treatment 
      of STSS associated with necrotizing fasciitis.
FAU - Cawley, M J
AU  - Cawley MJ
AD  - Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College 
      of Pharmacy, University of the Sciences in Philadelphia, Pennsylvania, USA.
FAU - Briggs, M
AU  - Briggs M
FAU - Haith, L R Jr
AU  - Haith LR Jr
FAU - Reilly, K J
AU  - Reilly KJ
FAU - Guilday, R E
AU  - Guilday RE
FAU - Braxton, G R
AU  - Braxton GR
FAU - Patton, M L
AU  - Patton ML
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Pharmacotherapy
JT  - Pharmacotherapy
JID - 8111305
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Adolescent
MH  - Combined Modality Therapy
MH  - Fasciitis, Necrotizing/pathology/*therapy
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Male
MH  - Shock, Septic/*therapy
MH  - Streptococcal Infections/complications/*therapy
MH  - Streptococcus pyogenes
EDAT- 1999/12/28 09:00
MHDA- 2001/03/28 10:01
CRDT- 1999/12/28 09:00
PHST- 1999/12/28 09:00 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1999/12/28 09:00 [entrez]
AID - 10.1592/phco.19.13.1094.31589 [doi]
PST - ppublish
SO  - Pharmacotherapy. 1999 Sep;19(9):1094-8. doi: 10.1592/phco.19.13.1094.31589.