PMID- 10611211
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20220317
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 15
IP  - 1
DP  - 2000 Jan
TI  - Evidence for major histocompatibility complex-mediated effects on spermatogenesis 
      in humans.
PG  - 189-96
AB  - Studies in fertile and infertile populations suggest an influence of genes of the 
      major histocompatibility complex (MHC) on reproduction, although it remains 
      unresolved if MHC-mediated effects on fertility are based on direct immunological 
      or non-immunological effects of human leukocyte antigen (HLA) genes or rather on 
      defects in MHC-associated non-HLA genes which affect gamete quality and embryonic 
      development. We analysed allele frequencies for HLA class II loci DQA1, DQB1 and 
      DRB1 and HLA class II haplotype frequencies in couples with tubal and 
      andrological infertility who were treated with assisted reproductive techniques. 
      Males with severe andrological infertility had significantly different allele 
      frequencies for all three HLA loci when compared to males with normozoospermia, 
      whereas no difference was found in the females. Differences in allele frequencies 
      were stronger when only males whose partners achieved pregnancies after assisted 
      reproduction treatment were compared. In those subgroups, we could also observe 
      significant differences in three locus HLA class II haplotype frequencies. In 
      summary, patients with male factor infertility differ in their HLA class II 
      allele constitution from males with normozoospermia, which suggests that genes 
      identical to or located in close vicinity to HLA class II genes may influence 
      spermatogenesis and male gamete function.
FAU - van der Ven, K
AU  - van der Ven K
AD  - Department of Obstetrics and Gynecology and Department of Medical Statistics, 
      University of Bonn, Sigmund-Freud-Strabetae 25, 53105 Bonn, Germany.
FAU - Fimmers, R
AU  - Fimmers R
FAU - Engels, G
AU  - Engels G
FAU - van der Ven, H
AU  - van der Ven H
FAU - Krebs, D
AU  - Krebs D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Infertility, Female/genetics
MH  - Infertility, Male/genetics
MH  - Male
MH  - Spermatogenesis/*genetics
EDAT- 1999/12/28 00:00
MHDA- 1999/12/28 00:01
CRDT- 1999/12/28 00:00
PHST- 1999/12/28 00:00 [pubmed]
PHST- 1999/12/28 00:01 [medline]
PHST- 1999/12/28 00:00 [entrez]
AID - 10.1093/humrep/15.1.189 [doi]
PST - ppublish
SO  - Hum Reprod. 2000 Jan;15(1):189-96. doi: 10.1093/humrep/15.1.189.