PMID- 10611266
OWN - NLM
STAT- MEDLINE
DCOM- 20000229
LR  - 20190513
IS  - 1360-9947 (Print)
IS  - 1360-9947 (Linking)
VI  - 6
IP  - 1
DP  - 2000 Jan
TI  - Lack of human leukocyte antigen-G expression in extravillous trophoblasts is 
      associated with pre-eclampsia.
PG  - 88-95
AB  - Pre-eclampsia, a common complication of first pregnancies, is thought to result 
      from a poorly perfused placenta and may reflect an abnormal maternal immune 
      reaction to the hemiallogenic fetus. Human leukocyte antigen (HLA)-G, a major 
      histocompatibility tissue-specific antigen expressed in extravillous trophoblast 
      cells (fetal-derived), may protect trophoblasts from maternal-fetal immune 
      intolerance and allow these cells to invade the uterus. Through RNA in-situ 
      hybridization analysis, we studied the expression pattern of HLA-G in normal 
      placentae and placentae from pregnancies complicated by severe pre-eclampsia. In 
      normal placenta we found HLA-G expression in the anchoring extravillous 
      trophoblasts with an increasing gradient of expression in the more invasive 
      cells. However, in nine out of 10 pre-eclamptic placentae HLA-G expression was 
      absent or reduced. We conclude that HLA-G is normally expressed in invasive 
      trophoblasts and HLA-G expression is defective in most pre-eclamptic placentae. 
      We propose that trophoblasts lacking HLA-G are vulnerable to attack by the 
      maternal immune system. These defective trophoblasts will be unable to invade the 
      maternal spiral arteries effectively, thereby developing vessels which cannot 
      adequately nourish the developing placenta. This poorly perfused placenta may 
      initiate the systemic cascade of events associated with pre-eclampsia.
FAU - Goldman-Wohl, D S
AU  - Goldman-Wohl DS
AD  - Department of Obstetrics and Gynecology and Department of Pathology, 
      Hadassah-University Hospital, Mt Scopus, Jerusalem, 91240, Israel, Samuel 
      Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, 
      Toronto, Ontario, Canada, M.
FAU - Ariel, I
AU  - Ariel I
FAU - Greenfield, C
AU  - Greenfield C
FAU - Hochner-Celnikier, D
AU  - Hochner-Celnikier D
FAU - Cross, J
AU  - Cross J
FAU - Fisher, S
AU  - Fisher S
FAU - Yagel, S
AU  - Yagel S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Hum Reprod
JT  - Molecular human reproduction
JID - 9513710
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Female
MH  - Gene Expression
MH  - HLA Antigens/*biosynthesis/genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*biosynthesis/genetics
MH  - Humans
MH  - Placenta/immunology/*metabolism/pathology
MH  - Pre-Eclampsia/immunology/*metabolism/pathology
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Pregnancy Trimester, Third
MH  - RNA
MH  - Trophoblasts/immunology/*metabolism
EDAT- 1999/12/28 09:00
MHDA- 2000/03/04 09:00
CRDT- 1999/12/28 09:00
PHST- 1999/12/28 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 1999/12/28 09:00 [entrez]
AID - 10.1093/molehr/6.1.88 [doi]
PST - ppublish
SO  - Mol Hum Reprod. 2000 Jan;6(1):88-95. doi: 10.1093/molehr/6.1.88.