PMID- 10611635
OWN - NLM
STAT- MEDLINE
DCOM- 20000217
LR  - 20061115
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 35
IP  - 2
DP  - 2000 Feb
TI  - Hemisynaptic distribution patterns of presenilins and beta-APP isoforms in the 
      rodent cerebellum and hippocampus.
PG  - 96-110
AB  - Healthy brain neurons co-express Alzheimer's disease (AD) related proteins 
      presenilins (PS) and beta-amyloid precursor protein (beta-APP). Deposition of 
      beta-amyloid and PS in the senile plaques of AD brain and their ability to 
      interact in vitro suggest that AD pathology could arise from a defect in the 
      physiological interactions between beta-APP and PS within and/or between neurons. 
      The present study compares the immunocytochemical distribution of PS (1 and 2) 
      and beta-APP major isoforms (695 and 751/770) in the synapses of the cerebellum 
      and hippocampus of the adult rat and mouse. In the cerebellar cortex of both 
      species, the four molecules are immunodetected in the presynaptic or the 
      postsynaptic compartments of synapses, suggesting that they are involved in 
      interneuronal relationships. In contrast, PS and beta-APP are postsynaptic in 
      almost all the immunoreactive synapses of the hippocampus. The different 
      distribution patterns of these proteins in cerebellar and hippocampal synapses 
      may reflect specific physiological differences, responsible for differential 
      vulnerability of neurons to AD synaptic pathology. Defective interactions between 
      beta-APP and PS at the synapses could impede the synaptic functions of beta-APP, 
      inducing the selective loss of synapses that accounts for cognitive impairment in 
      AD.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Ribaut-Barassin, C
AU  - Ribaut-Barassin C
AD  - Laboratoire de Neurobiologie Cellulaire CNRS UPR 9009, Strasbourg, France.
FAU - Moussaoui, S
AU  - Moussaoui S
FAU - Brugg, B
AU  - Brugg B
FAU - Haeberle, A M
AU  - Haeberle AM
FAU - Huber, G
AU  - Huber G
FAU - Imperato, A
AU  - Imperato A
FAU - Delhaye-Bouchaud, N
AU  - Delhaye-Bouchaud N
FAU - Mariani, J
AU  - Mariani J
FAU - Bailly, Y J
AU  - Bailly YJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Membrane Proteins)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*analysis
MH  - Animals
MH  - Cerebellum/*cytology/ultrastructure
MH  - Hippocampus/*cytology/ultrastructure
MH  - Immunohistochemistry
MH  - Membrane Proteins/*analysis
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Microscopy, Immunoelectron
MH  - Protein Isoforms/analysis
MH  - Rats
MH  - Rats, Long-Evans
MH  - Synapses/*ultrastructure
EDAT- 1999/12/28 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/12/28 09:00
PHST- 1999/12/28 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/12/28 09:00 [entrez]
AID - 10.1002/(SICI)1098-2396(200002)35:2<96::AID-SYN2>3.0.CO;2-0 [pii]
AID - 10.1002/(SICI)1098-2396(200002)35:2<96::AID-SYN2>3.0.CO;2-0 [doi]
PST - ppublish
SO  - Synapse. 2000 Feb;35(2):96-110. doi: 
      10.1002/(SICI)1098-2396(200002)35:2<96::AID-SYN2>3.0.CO;2-0.