PMID- 10611642
OWN - NLM
STAT- MEDLINE
DCOM- 20000217
LR  - 20140325
IS  - 0887-4476 (Print)
IS  - 0887-4476 (Linking)
VI  - 35
IP  - 2
DP  - 2000 Feb
TI  - Enhancement of conditioned place preference response to cocaine in rats following 
      subchronic administration of 3, 4-methylenedioxymethamphetamine (MDMA).
PG  - 160-2
AB  - In this study, we measured conditioned place preference (CPP) responses to 
      cocaine following subchronic administration of the recreationally abused drug 
      (+/-)-3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in male Sprague-Dawley 
      rats. Animals were given either vehicle (1 ml/kg of distilled water, s.c.) or 
      MDMA (20 mg/kg, s.c.) twice a day for 4 consecutive days. Two weeks later, CPP 
      responses to cocaine (5, 10, or 20 mg/kg, i.p.) were measured. The MDMA-treated 
      animals showed a significantly greater CPP response to cocaine than the 
      vehicle-treated animals. Since conditioned place preference is believed to be a 
      measure of appetitive behavior, these results suggest that MDMA abuse could lead 
      to an increased vulnerability to the rewarding actions of cocaine and, hence, to 
      increased vulnerability to cocaine addiction and dependence.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Horan, B
AU  - Horan B
AD  - PHS Department, College of Pharmacy and Allied Health Professions, St. John's 
      University, Jamaica, New York 11439, USA.
FAU - Gardner, E L
AU  - Gardner EL
FAU - Ashby, C R Jr
AU  - Ashby CR Jr
LA  - eng
GR  - R29MH55155/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Synapse
JT  - Synapse (New York, N.Y.)
JID - 8806914
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Appetite/drug effects/physiology
MH  - Choice Behavior/*physiology
MH  - Cocaine/*pharmacology
MH  - Conditioning, Operant/drug effects/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reward
EDAT- 1999/12/28 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/12/28 09:00
PHST- 1999/12/28 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/12/28 09:00 [entrez]
AID - 10.1002/(SICI)1098-2396(200002)35:2<160::AID-SYN9>3.0.CO;2-O [pii]
AID - 10.1002/(SICI)1098-2396(200002)35:2<160::AID-SYN9>3.0.CO;2-O [doi]
PST - ppublish
SO  - Synapse. 2000 Feb;35(2):160-2. doi: 
      10.1002/(SICI)1098-2396(200002)35:2<160::AID-SYN9>3.0.CO;2-O.