PMID- 10611756
OWN - NLM
STAT- MEDLINE
DCOM- 20000223
LR  - 20191103
IS  - 1286-4579 (Print)
IS  - 1286-4579 (Linking)
VI  - 1
IP  - 15
DP  - 1999 Dec
TI  - TGF-beta1 regulation of dendritic cells.
PG  - 1283-90
AB  - Dendritic cells (DCs) represent antigen-presenting cell (APC) populations in 
      lymphoid and nonlymphoid organs which are considered to play key roles in the 
      initiation of antigen-specific T-cell proliferation. According to current 
      knowledge, the net outcome of T-cell immune responses seems to be significantly 
      influenced by the activation stage of antigen-presenting DCs. Several studies 
      have shown that transforming growth factor-beta 1 (TGF-beta1) inhibits in vitro 
      activation and maturation of DCs. TGF-beta1 inhibits upregulation of critical 
      T-cell costimulatory molecules on the surface of DCs and reduces the 
      antigen-presenting capacity of DCs. Thus, in addition to direct inhibitory 
      effects of TGF-beta1 on effector T lymphocytes, inhibitory effects of TGF-beta1 
      at the level of APCs may critically contribute to previously characterized 
      immunosuppressive effects of TGF-beta1. In contrast to these negative regulatory 
      effects of TGF-beta1 on function and maturation of lymphoid tissue type DCs, 
      certain subpopulations of immature DCs in nonlymphoid tissues are positively 
      regulated by TGF-beta1 signaling. In particular, epithelial-associated DC 
      populations seem to critically require TGF-beta1 stimulation for development and 
      function. Recent studies established that TGF-beta1 stimulation is absolutely 
      required for the development of epithelial Langerhans cells (LCs) in vitro and in 
      vivo. Furthermore, TGF-beta1 seems to enhance antigen processing and 
      costimulatory functions of epithelial LCs.
FAU - Strobl, H
AU  - Strobl H
AD  - Institute of Immunology, University of Vienna, Borschkegasse 8a, 1090 Vienna, 
      Austria.
FAU - Knapp, W
AU  - Knapp W
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Microbes Infect
JT  - Microbes and infection
JID - 100883508
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/physiology
MH  - Dendritic Cells/*metabolism
MH  - Humans
MH  - T-Lymphocytes/physiology
MH  - Transforming Growth Factor beta/*physiology
RF  - 67
EDAT- 1999/12/28 09:00
MHDA- 2000/02/26 09:00
CRDT- 1999/12/28 09:00
PHST- 1999/12/28 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 1999/12/28 09:00 [entrez]
AID - S1286-4579(99)00256-7 [pii]
AID - 10.1016/s1286-4579(99)00256-7 [doi]
PST - ppublish
SO  - Microbes Infect. 1999 Dec;1(15):1283-90. doi: 10.1016/s1286-4579(99)00256-7.