PMID- 10614642
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20230919
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 141
IP  - 1
DP  - 2000 Jan
TI  - N-methyl D,L-aspartate induces the release of luteinizing hormone-releasing 
      hormone in the prepubertal and pubertal female rhesus monkey as measured by in 
      vivo push-pull perfusion in the stalk-median eminence.
PG  - 219-28
AB  - The role of the excitatory amino acid glutamate, N-methyl D-aspartate (NMDA) 
      receptor agonist, in stimulating in vivo luteinizing hormone-releasing hormone 
      (LHRH) release in the stalk-median eminence of conscious prepubertal and pubertal 
      female rhesus monkeys was evaluated using push-pull perfusion. In Exp 1, the 
      effects of i.v. bolus injection of N-methyl D,L-aspartate (NMA) on LHRH release 
      were examined. Injection of NMA induced an increase in LHRH release in all 
      maturational stages of monkeys. Although the LHRH response to NMA tended to be 
      larger in the older groups, only the duration of the LHRH response in the 
      midpubertal group was significantly longer than that in the prepubertal group. In 
      Exp 2, the effects of direct infusion of NMA (0.1, 1, and 100 microM) into the 
      stalk-median eminence on LHRH release were similarly examined. NMA infusion 
      stimulated LHRH release in pubertal monkeys, whereas it did not induce any 
      consistent changes in LHRH release in prepubertal monkeys except for the highest 
      dose. These data suggest that: 1) the systemic injection of NMA is more effective 
      than direct infusion of NMA; and 2) the prepubertal LHRH neurosecretory system is 
      capable of responding to NMDA, although the responsiveness may undergo 
      developmental changes. Therefore, stimulation of NMDA receptors may contribute to 
      the pubertal changes in the LHRH neurosecretory activity.
FAU - Claypool, L E
AU  - Claypool LE
AD  - Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 
      53715-1299, USA.
FAU - Kasuya, E
AU  - Kasuya E
FAU - Saitoh, Y
AU  - Saitoh Y
FAU - Marzban, F
AU  - Marzban F
FAU - Terasawa, E
AU  - Terasawa E
LA  - eng
GR  - HD-11533/HD/NICHD NIH HHS/United States
GR  - HD-15433/HD/NICHD NIH HHS/United States
GR  - RR-00167/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 6384-92-5 (N-Methylaspartate)
SB  - IM
MH  - Animals
MH  - Excitatory Amino Acid Agonists/*pharmacology
MH  - Female
MH  - Gonadotropin-Releasing Hormone/*metabolism
MH  - Macaca mulatta
MH  - Median Eminence/drug effects/*metabolism
MH  - N-Methylaspartate/*pharmacology
MH  - Perfusion
MH  - Sexual Maturation/*physiology
EDAT- 1999/12/30 00:00
MHDA- 1999/12/30 00:01
CRDT- 1999/12/30 00:00
PHST- 1999/12/30 00:00 [pubmed]
PHST- 1999/12/30 00:01 [medline]
PHST- 1999/12/30 00:00 [entrez]
AID - 10.1210/endo.141.1.7231 [doi]
PST - ppublish
SO  - Endocrinology. 2000 Jan;141(1):219-28. doi: 10.1210/endo.141.1.7231.