PMID- 10616524
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 116
IP  - 1
DP  - 2000 Jan 1
TI  - Fluorescence in situ hybridization study of aneuploidy of chromosomes 7, 10, X, 
      and Y in primary and secondary glioblastomas.
PG  - 6-9
AB  - The aneuploidy of autosomes 7, 10, and sex chromosomes (X and Y) was analyzed in 
      a series of 44 primary (de novo) and 20 secondary glioblastomas using 
      fluorescence in situ hybridization (FISH) on smear preparations of glioma tissue. 
      The tumors were screened for trisomy 7, monosomy 10, as well as loss of the Y 
      chromosome and disomy of the X chromosome in male subjects, and monosomy of the X 
      chromosome in female subjects. We found that taken alone or in combination, these 
      chromosomal abnormalities do not appear to be characteristic of a glioblastoma 
      subtype; therefore, they do not allow the differentiation between primary and 
      secondary glioblastomas. Also, the loss of a chromosome 10 appears to be an 
      earlier event than a gain of a chromosome 7 for the genesis of a secondary 
      glioblastoma.
FAU - Amalfitano, G
AU  - Amalfitano G
AD  - Laboratory of Neuro-Oncology, University of Nice-Sophia Antipolis, France.
FAU - Chatel, M
AU  - Chatel M
FAU - Paquis, P
AU  - Paquis P
FAU - Michiels, J F
AU  - Michiels JF
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - *Aneuploidy
MH  - Brain Neoplasms/etiology/*genetics
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 10
MH  - Chromosomes, Human, Pair 7
MH  - Female
MH  - Glioblastoma/etiology/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Monosomy
MH  - Trisomy
MH  - X Chromosome
MH  - Y Chromosome
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - S0165-4608(99)00089-8 [pii]
AID - 10.1016/s0165-4608(99)00089-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Jan 1;116(1):6-9. doi: 
      10.1016/s0165-4608(99)00089-8.