PMID- 10616538
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 116
IP  - 1
DP  - 2000 Jan 1
TI  - Cytogenetic triclonality in T-cell acute lymphoblastic leukemia: a conventional 
      and molecular cytogenetic study.
PG  - 77-80
AB  - Cytogenetically-unrelated clones are infrequently seen in hematologic 
      malignancies, and are particularly uncommon in acute lymphoblastic leukemia. We 
      report a case of T-cell acute lymphoblastic leukemia with L2 morphology which 
      demonstrated three cytogenetically distinct clones: 
      46,XY,t(2;9)(p21;q34)/46,XY,del(6)(q21q23)/47,XX,+8. Interphase cytogenetic 
      analysis by fluorescence in situ hybridization (FISH) confirmed the presence of 
      trisomy 8 in a significant proportion of lymphoblasts, while reverse 
      transcription-polymerase chain reaction (RT-PCR) did not show the presence of 
      BCR/ABL fusion. This is the first report describing the occurrence of cytogenetic 
      triclonality in de novo T-cell acute lymphoblastic leukemia.
FAU - Wong, K F
AU  - Wong KF
AD  - Department of Pathology, Queen Elizabeth Hospital, Hong Kong, S. A. R. China.
FAU - So, C C
AU  - So CC
FAU - Siu, L P
AU  - Siu LP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Child
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 2
MH  - Chromosomes, Human, Pair 6
MH  - Chromosomes, Human, Pair 8
MH  - Chromosomes, Human, Pair 9
MH  - *Cytogenetic Analysis
MH  - Gene Deletion
MH  - Gene Duplication
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia-Lymphoma, Adult T-Cell/*genetics
MH  - Male
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Translocation, Genetic
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - S0165-4608(99)00096-5 [pii]
AID - 10.1016/s0165-4608(99)00096-5 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Jan 1;116(1):77-80. doi: 
      10.1016/s0165-4608(99)00096-5.