PMID- 10616934
OWN - NLM
STAT- MEDLINE
DCOM- 20000131
LR  - 20190826
IS  - 0033-2917 (Print)
IS  - 0033-2917 (Linking)
VI  - 29
IP  - 6
DP  - 1999 Nov
TI  - The efficacy of drug treatments for dysthymia: a systematic review and 
      meta-analysis.
PG  - 1273-89
AB  - BACKGROUND: Dysthymia is a common mental disorder, associated with considerable 
      disability and high co-morbidity. This review assessed the role of 
      pharmacological treatment. METHODS: All randomized-controlled trials that 
      compared active drug versus placebo for dysthymic patients were included. Pooled 
      relative risks (RR) and 95% confidence intervals (CI) were calculated with the 
      Random Effect Model method. Where possible, number needed to treat and number 
      needed to harm were estimated. RESULTS: Fifteen trials were included for the main 
      comparisons. Similar results were obtained in terms of efficacy for different 
      groups of drugs, such as tricyclic (TCA), selective serotonin reuptake inhibitors 
      (SSRI), monoamine oxidase inhibitors (MAOI) and other drugs (sulpiride, 
      amineptine, and ritanserin). The pooled RR treatment response was 0.68 (95% CI 
      0.59-0.78) for TCA, 0.64 (95% CI 0.55-0.74) for SSRIs, 0.59 (95% CI 0.48-0.71) 
      for MAOIs. Other drugs (amisulpride, amineptine and ritanserin) showed similar 
      results. Patients treated on TCA were more likely to report adverse events, 
      compared with placebo. There were no differences in response to active treatment 
      when dysthymia was compared to either dysthymia plus major depression or briefer 
      non-major depressive states. CONCLUSIONS: Drug treatment appears to be effective 
      in the short-term management of dysthymic disorder. The choice of drug should 
      take into account specific side-effects profile of each drug.
FAU - de Lima, M S
AU  - de Lima MS
AD  - Departamento de Saude Mental, Faculdade de Medicina, Universidade Federal de 
      Pelotas, RS, Brazil.
FAU - Hotoph, M
AU  - Hotoph M
FAU - Wessely, S
AU  - Wessely S
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Antidepressive Agents/adverse effects/*therapeutic use
MH  - Dysthymic Disorder/diagnosis/*drug therapy/psychology
MH  - Humans
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - 10.1017/s0033291799001324 [doi]
PST - ppublish
SO  - Psychol Med. 1999 Nov;29(6):1273-89. doi: 10.1017/s0033291799001324.