PMID- 10616960
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20190831
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 67
IP  - 1
DP  - 1999 Oct
TI  - Inhibition of immediate-type allergic reaction by Rosa davurica Pall. in a murine 
      model.
PG  - 53-60
AB  - We studied the effect of Rosa davurica Pall. (Rosaceae) fruits (RdF) on 
      immediate-type allergic reactions. RdF completely inhibited compound 
      48/80-induced systemic anaphylactic shock at the dose of 1 g/kg. When RdF was 
      given as pretreatment, at concentrations ranging from 0.0001 to 1 g/kg, the serum 
      histamine levels induced by compound 48/80 were reduced in a dose-dependent 
      manner. RdF inhibited the passive cutaneous anaphylaxis activated by 
      anti-dinitrophenyl (DNP) IgE antibody dose dependently. RdF also inhibited the 
      histamine release induced by compound 48/80 or anti-DNP IgE from the rat 
      peritoneal mast cells (RPMC). Moreover, RdF had a significant inhibitory effect 
      on anti-DNP IgE-induced tumor necrosis factor-alpha production from RPMC. These 
      results indicate that RdF may contain compounds with actions that inhibit mast 
      cell degranulation in the rat.
FAU - Kim, H M
AU  - Kim HM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea. hmkim@med.wonkwang.ac.kr
FAU - Park, Y A
AU  - Park YA
FAU - Lee, E J
AU  - Lee EJ
FAU - Shin, T Y
AU  - Shin TY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - *Anaphylaxis
MH  - Animals
MH  - Anti-Allergic Agents/*pharmacology
MH  - Cell Line
MH  - Chromatography, High Pressure Liquid
MH  - Disease Models, Animal
MH  - Histamine Release/drug effects
MH  - Korea
MH  - Male
MH  - Mast Cells/drug effects
MH  - *Medicine, East Asian Traditional
MH  - Passive Cutaneous Anaphylaxis/*drug effects
MH  - Plant Extracts/*pharmacology
MH  - *Plants, Medicinal
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - p-Methoxy-N-methylphenethylamine
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - S0378874199000136 [pii]
AID - 10.1016/s0378-8741(99)00013-6 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 1999 Oct;67(1):53-60. doi: 10.1016/s0378-8741(99)00013-6.