PMID- 10619312
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20190513
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 54
IP  - 11
DP  - 1999 Nov
TI  - Growth curves and survival characteristics of the animals used in the Biomarkers 
      of Aging Program.
PG  - B492-501
AB  - The collaborative Interagency Agreement between the National Center for 
      Toxicological Research (NCTR) and the National Institute on Aging (NIA) was aimed 
      at identifying and validating a panel of biomarkers of aging in rodents in order 
      to rapidly test the efficacy and safety of interventions designed to slow aging. 
      Another aim was to provide a basis for developing biomarkers of aging in humans, 
      using the assumption that biomarkers that were useful across different genotypes 
      and species were sensitive to fundamental processes that would extrapolate to 
      humans. Caloric restriction (CR), the only intervention that consistently extends 
      both mean and maximal life span in a variety of species, was used to provide a 
      model with extended life span. C57BI/6NNia, DBA/2JNia, B6D2F1, and B6C3F1 mice 
      and Brown Norway (BN/RijNia), Fischer (F344/NNia) and Fischer x Brown Norway 
      hybrid (F344 x BN F1) rats were bred and maintained on study. NCTR generated data 
      from over 60,000 individually housed animals of the seven different genotypes and 
      both sexes, approximately half ad libitum (AL) fed, the remainder CR. 
      Approximately half the animals were shipped to offsite NIA investigators 
      internationally, with the majority of the remainder maintained at NCTR until they 
      died. The collaboration supplied a choice of healthy, long-lived rodent models to 
      investigators, while allowing for the development of some of the most definitive 
      information on life span, food consumption, and growth characteristics in these 
      genotypes under diverse feeding paradigms.
FAU - Turturro, A
AU  - Turturro A
AD  - Division of Biometry and Risk Assessment, National Center for Toxicological 
      Research, Food and Drug Administration, Jefferson, Arkansas 72079-9502, USA. 
      aturturro@nctr.fda.gov
FAU - Witt, W W
AU  - Witt WW
FAU - Lewis, S
AU  - Lewis S
FAU - Hass, B S
AU  - Hass BS
FAU - Lipman, R D
AU  - Lipman RD
FAU - Hart, R W
AU  - Hart RW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Biomarkers
MH  - Body Weight
MH  - Eating
MH  - Female
MH  - *Growth
MH  - *Longevity
MH  - Male
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Rats
MH  - Rats, Inbred BN
MH  - Rats, Inbred F344
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - 10.1093/gerona/54.11.b492 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 1999 Nov;54(11):B492-501. doi: 
      10.1093/gerona/54.11.b492.