PMID- 10619337
OWN - NLM
STAT- MEDLINE
DCOM- 20000114
LR  - 20130520
IS  - 1081-1206 (Print)
IS  - 1081-1206 (Linking)
VI  - 83
IP  - 6 Pt 2
DP  - 1999 Dec
TI  - Mechanisms of occupational asthma.
PG  - 645-64
AB  - The pathogenesis and the pathologic alterations of occupational asthma are 
      similar to those of nonoccupational asthma. Occupational asthma may therefore 
      represent a useful model of "human asthma" to investigate mechanisms and 
      pathophysiology of asthma in general. In an occupational setting the cause and 
      onset of asthma may be easily identified, and the natural history may be examined 
      in follow-up studies. The mechanisms involved in occupational asthma include 
      genetic predisposition, immunologically mediated responses, as well as 
      nonspecific airway inflammation. In particular, high molecular weight (eg, grain 
      dust, flour) and some low molecular weight sensitizers (eg, acid anhydrides and 
      platinum halide salts) have been shown to induce occupational asthma through an 
      immunoglobulin E (IgE)-dependent mechanism, while cell-dependent immunologic 
      mechanisms are likely to be more relevant for occupational asthma induced by 
      other low molecular weight sensitizers (eg, toluene diisocyanate and plicatic 
      acid contained in western red cedar). The pathology of the airway mucosa of 
      occupational asthma is remarkably similar to the pathology of nonoccupational 
      asthma, ie, characterized by infiltration and accumulation of eosinophils, mast 
      cells, and activated lymphocytes along with subepithelial fibrosis. In this 
      article, the most relevant mechanisms are discussed with particular reference to 
      the similarities and discrepancies between occupational and nonoccupational 
      asthma.
FAU - Mapp, C
AU  - Mapp C
AD  - Institute of Occupational Medicine, University of Padova, Italy.
FAU - Boschetto, P
AU  - Boschetto P
FAU - Miotto, D
AU  - Miotto D
FAU - De Rosa, E
AU  - De Rosa E
FAU - Fabbri, L M
AU  - Fabbri LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
SB  - IM
MH  - Asthma/*physiopathology
MH  - Humans
MH  - Occupational Diseases/*physiopathology
RF  - 219
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - S1081-1206(10)62888-8 [pii]
AID - 10.1016/S1081-1206(10)62888-8 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 1999 Dec;83(6 Pt 2):645-64. doi: 
      10.1016/S1081-1206(10)62888-8.