PMID- 10619564
OWN - NLM
STAT- MEDLINE
DCOM- 20000114
LR  - 20091119
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 160
IP  - 2
DP  - 1999 Dec
TI  - Mild experimental brain injury differentially alters the expression of 
      neurotrophin and neurotrophin receptor mRNAs in the hippocampus.
PG  - 469-78
AB  - The molecular events responsible for impairments in cognition following mild 
      traumatic brain injury are poorly understood. Neurotrophins, such as 
      brain-derived neurotrophic factor (BDNF), have been identified as having a role 
      in learning and memory. We have previously demonstrated that following 
      experimental brain trauma of moderate severity (2.0-2.1 atm), mRNA levels of BDNF 
      and its high-affinity receptor, trkB, are increased bilaterally in the 
      hippocampus for several hours, whereas NT-3 mRNA expression is decreased. In the 
      present study, we used in situ hybridization to compare BDNF, trkB, NT-3, and 
      trkC mRNA expression in rat hippocampus at 3 or 6 h after a lateral fluid 
      percussion brain injury (FPI) of mild severity (1.0 atm) to sham-injured controls 
      at equivalent time points. Mild FPI induced significant increases in 
      hybridization levels for BDNF and trkB mRNAs, and a decrease in NT-3 mRNA in the 
      hippocampus. However, in contrast to the bilateral effects of moderate 
      experimental brain injury, the present changes with mild injury were restricted 
      to the injured side. These findings demonstrate that even a mild traumatic brain 
      injury differentially alters neurotrophin and neurotrophin receptor levels in the 
      hippocampus. Such alterations may have important implications for neural 
      plasticity and recovery of function in people who sustain a mild head injury.
FAU - Hicks, R R
AU  - Hicks RR
AD  - Division of Physical Therapy, University of Kentucky, Lexington 40536, USA.
FAU - Martin, V B
AU  - Martin VB
FAU - Zhang, L
AU  - Zhang L
FAU - Seroogy, K B
AU  - Seroogy KB
LA  - eng
GR  - NS35164/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Animals
MH  - Brain Injuries/*metabolism/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dentate Gyrus/metabolism
MH  - Functional Laterality
MH  - *Gene Expression Regulation
MH  - Hippocampus/*metabolism
MH  - In Situ Hybridization
MH  - Male
MH  - Neurotrophin 3/*genetics
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*genetics
MH  - Receptor, trkC/*genetics
MH  - Time Factors
MH  - *Transcription, Genetic
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - S0014-4886(99)97216-3 [pii]
AID - 10.1006/exnr.1999.7216 [doi]
PST - ppublish
SO  - Exp Neurol. 1999 Dec;160(2):469-78. doi: 10.1006/exnr.1999.7216.