PMID- 10619646
OWN - NLM
STAT- MEDLINE
DCOM- 20000119
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 10
IP  - 17
DP  - 1999 Nov 26
TI  - Retinoic acid increases BDNF-dependent regeneration of chick retinal ganglion 
      cells in vitro.
PG  - 3573-7
AB  - Brain-derived neurotrophic factor (BDNF) supports survival and regeneration of 
      retinal ganglion cells (RGC). Since the expression of its receptor TrkB can be 
      induced by the transcriptional activator retinoic acid (RA), we have investigated 
      the possibility that RA promotes axonal regeneration of differentiated chick RGC 
      synergistically with BDNF. After injection of all-trans RA onto the 
      chorio-allantoic membrane of stage E16 chick embryos, axonal regeneration was 
      monitored in organ cultures supplemented with BDNF. RA enhanced neurite outgrowth 
      of retinal ganglion cells 2- to 3-fold. The dose-dependent effect was observed 
      only after application of RA in ovo and subsequent use of the neurotrophin, not 
      with RA alone.
FAU - Mey, J
AU  - Mey J
AD  - Institut fur Biologie II, RWTH Aachen, Germany.
FAU - Rombach, N
AU  - Rombach N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Axons/*drug effects/physiology
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cell Differentiation/drug effects
MH  - Cell Size/drug effects
MH  - Chick Embryo
MH  - Dose-Response Relationship, Drug
MH  - Drug Synergism
MH  - Nerve Growth Factors/pharmacology
MH  - Nerve Regeneration/*drug effects
MH  - Neurites/drug effects/physiology
MH  - Organ Culture Techniques
MH  - Retinal Ganglion Cells/cytology/*drug effects
MH  - Tretinoin/*pharmacology
MH  - Vitelline Membrane
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - 10.1097/00001756-199911260-00020 [doi]
PST - ppublish
SO  - Neuroreport. 1999 Nov 26;10(17):3573-7. doi: 10.1097/00001756-199911260-00020.