PMID- 10619665
OWN - NLM
STAT- MEDLINE
DCOM- 20000119
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 10
IP  - 17
DP  - 1999 Nov 26
TI  - Alpha-lipoic acid prevents 3,4-methylenedioxy-methamphetamine (MDMA)-induced 
      neurotoxicity.
PG  - 3675-80
AB  - A single administration of 3,4-methylenedioxymethamphetamine (MDMA, 20 mg/kg, 
      i.p.), induced significant hyperthermia in rats and reduced 5-hydroxytryptamine 
      (5-HT) content and [3H]paroxetine-labeled 5-HT transporter density in the frontal 
      cortex, striatum and hippocampus by 40-60% 1 week later. MDMA treatment also 
      increased glial fibrillary acidic protein (GFAP) immunoreactivity in the 
      hippocampus. Repeated administration of the metabolic antioxidant alpha-lipoic 
      acid (100 mg/kg, i.p., b.i.d. for 2 consecutive days) 30 min prior to MDMA did 
      not prevent the acute hyperthermia induced by the drug; however, it fully 
      prevented the serotonergic deficits and the changes in the glial response induced 
      by MDMA. These results further support the hypothesis that free radical formation 
      is responsible for MDMA-induced neurotoxicity.
FAU - Aguirre, N
AU  - Aguirre N
AD  - Department of Pharmacology, School of Medicine, University of Navarra, Pamplona, 
      Spain.
FAU - Barrionuevo, M
AU  - Barrionuevo M
FAU - Ramirez, M J
AU  - Ramirez MJ
FAU - Del Rio, J
AU  - Del Rio J
FAU - Lasheras, B
AU  - Lasheras B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Antioxidants)
RN  - 0 (Carrier Proteins)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Slc6a4 protein, rat)
RN  - 333DO1RDJY (Serotonin)
RN  - 41VRH5220H (Paroxetine)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Antioxidants/pharmacology
MH  - Astrocytes/drug effects/metabolism
MH  - Binding Sites/drug effects
MH  - Carrier Proteins/metabolism
MH  - Fever/chemically induced
MH  - Frontal Lobe/cytology/*drug effects/metabolism
MH  - Glial Fibrillary Acidic Protein/analysis
MH  - Hippocampus/cytology/*drug effects/metabolism
MH  - Hypothermia/chemically induced
MH  - Male
MH  - Membrane Glycoproteins/metabolism
MH  - *Membrane Transport Proteins
MH  - N-Methyl-3,4-methylenedioxyamphetamine/antagonists & inhibitors/*toxicity
MH  - Neostriatum/cytology/*drug effects/metabolism
MH  - *Nerve Tissue Proteins
MH  - Neuroprotective Agents/*pharmacology
MH  - Paroxetine/metabolism
MH  - Pyramidal Cells/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/metabolism
MH  - Serotonin Plasma Membrane Transport Proteins
MH  - Thioctic Acid/*pharmacology
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - 10.1097/00001756-199911260-00039 [doi]
PST - ppublish
SO  - Neuroreport. 1999 Nov 26;10(17):3675-80. doi: 10.1097/00001756-199911260-00039.