PMID- 10619944
OWN - NLM
STAT- MEDLINE
DCOM- 20000224
LR  - 20190905
IS  - 1464-4096 (Print)
IS  - 1464-4096 (Linking)
VI  - 85
IP  - 1
DP  - 2000 Jan
TI  - Aneusomy of chromosomes 7 and 17 predicts the recurrence of transitional cell 
      carcinoma of the urinary bladder.
PG  - 42-7
AB  - OBJECTIVE: To determine if changes in chromosome 7 and 17 copy number can be used 
      to predict recurrence in patients with primary noninvasive (pTa) or superficially 
      invasive (pT1) transitional cell carcinoma (TCC) of the urinary bladder. PATIENTS 
      AND METHODS: Tissue specimens for 129 tumours from 52 patients (38 men and 14 
      women) with pTa/pT1 TCC at first diagnosis were retrieved from pathology 
      archives. All patient notes were accessed and disease outcome documented for 
      superficial (pTa/pT1) recurrence or progression to detrusor muscle invasion (>/= 
      pT2). The tumours were examined for chromosomal copy number of chromosomes 7 and 
      17 using fluorescence in situ hybridization (FISH) with chromosome-specific 
      probes. The copy number of chromosomes 7 and 17 was determined in interphase 
      nuclei on intact 6 microm tissue sections. RESULTS: Aneusomy of chromosomes 7 and 
      17 was detected in the index primary tumours of 10 of 32 (31%) patients with 
      subsequent recurrent disease. No aneusomy for these chromosomes was detected in 
      primary tumours from 20 patients with no detect-able recurrence (P = 0.0082). The 
      relative risk of recurrence was 3.62 times greater (95% confidence interval 
      1.6-8.1, Cox's multiple regression P = 0.0019) for patients with chromosomal 
      aneusomy in primary TCC. Neither stage nor grade of the primary tumours was 
      associated with recurrence in these patients, nor was there a significant 
      association with increased grade (G2/3) or stage (>/= pT2) at recurrence. 
      CONCLUSION: These results suggest that the measurement of aneusomy by FISH, using 
      markers for chromosomes 7 and 17, predict recurrence in a subgroup of patients 
      with pTa/pT1 tumours at presentation. This finding may offer a new objective and 
      quantitative test for patients destined to recur.
FAU - Watters, A D
AU  - Watters AD
AD  - University Department of Surgery, Glasgow Royal Infirmary, Scotland.
FAU - Ballantyne, S A
AU  - Ballantyne SA
FAU - Going, J J
AU  - Going JJ
FAU - Grigor, K M
AU  - Grigor KM
FAU - Bartlett, J M
AU  - Bartlett JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - BJU Int
JT  - BJU international
JID - 100886721
SB  - IM
MH  - Aged
MH  - *Aneuploidy
MH  - Carcinoma, Transitional Cell/*genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Neoplasm Recurrence, Local/*genetics
MH  - Retrospective Studies
MH  - Urinary Bladder Neoplasms/*genetics
EDAT- 2000/01/05 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/01/05 09:00
PHST- 2000/01/05 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/01/05 09:00 [entrez]
AID - bju326 [pii]
AID - 10.1046/j.1464-410x.2000.00326.x [doi]
PST - ppublish
SO  - BJU Int. 2000 Jan;85(1):42-7. doi: 10.1046/j.1464-410x.2000.00326.x.