PMID- 10623429
OWN - NLM
STAT- MEDLINE
DCOM- 20000308
LR  - 20071114
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 11
IP  - 12
DP  - 1999 Dec
TI  - Expression and regulation of chemokine genes in the mouse uterus during 
      pregnancy.
PG  - 1038-45
AB  - Leukocytes accumulate in the pregnant mouse uterus following mating, during 
      implantation and during placental development. Changes in leukocyte number are 
      primarily due to recruitment from the blood, not local proliferation, but the 
      underlying recruitment mechanisms are poorly understood. Mating-induced 
      granulocyte and macrophage recruitment is due in part to pro-inflammatory and 
      chemotactic factors present in seminal plasma. Accumulation of macrophages later 
      in pregnancy appears to be caused in part by ovarian hormone-stimulated CSF-1 
      production and in part by other as yet unidentified uterine chemotactic factors. 
      The current study was performed to assess chemokine production in the uterus 
      during pregnancy. Northern blotting was used to demonstrate NSI/KC (KC), 
      macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein one 
      alpha (MIP1alpha) and regulated inactivation, normal T expressed and secreted 
      protein (RANTES) mRNA in the uterus. Oestrogen and progesterone induced 
      intrauterine production of all four chemokines and may have done so through the 
      autocrine/paracrine activities of IL-1. The data suggest that C-C chemokines play 
      a role in accumulation of macrophages in the uterus during pregnancy.
CI  - Copyright 1999 Academic Press.
FAU - Wood, G W
AU  - Wood GW
AD  - Department of Pathology and Laboratory Medicine, University of Kansas Medical 
      Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160-7410, USA.
FAU - Hausmann, E H
AU  - Hausmann EH
FAU - Kanakaraj, K
AU  - Kanakaraj K
LA  - eng
GR  - HD30802/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Chemokines)
SB  - IM
MH  - Animals
MH  - Chemokines/*genetics
MH  - Female
MH  - *Gene Expression Regulation
MH  - Mice
MH  - Pregnancy
MH  - Pregnancy, Animal/*genetics/immunology
MH  - Uterus/physiology
EDAT- 2000/01/07 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/01/07 09:00
PHST- 2000/01/07 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/01/07 09:00 [entrez]
AID - S1043-4666(99)90513-6 [pii]
AID - 10.1006/cyto.1999.0513 [doi]
PST - ppublish
SO  - Cytokine. 1999 Dec;11(12):1038-45. doi: 10.1006/cyto.1999.0513.