PMID- 10623879
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20131121
IS  - 0021-9541 (Print)
IS  - 0021-9541 (Linking)
VI  - 182
IP  - 2
DP  - 2000 Feb
TI  - Multi-faceted regulation of gamma-glutamylcysteine synthetase.
PG  - 163-70
AB  - Glutathione is an important antioxidant that is involved in numerous cellular 
      activities. gamma-Glutamylcysteine synthetase (gammaGCS) is a key regulatory 
      enzyme in the synthesis of glutathione. It is a heterodimeric zinc metalloprotein 
      that belongs to a unique class of proteins that gain activity due to formation of 
      a reversible disulfide bond. The two subunits of gammaGCS exhibit differential 
      and coordinate transcription regulation. In addition, the subunits are regulated 
      at the posttranscriptional and posttranslational levels. These various levels of 
      regulation allow numerous stimuli to induce or inhibit activity.
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Soltaninassab, S R
AU  - Soltaninassab SR
AD  - Department of Radiation Oncology, Vanderbilt University School of Medicine and 
      Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA.
FAU - Sekhar, K R
AU  - Sekhar KR
FAU - Meredith, M J
AU  - Meredith MJ
FAU - Freeman, M L
AU  - Freeman ML
LA  - eng
GR  - CA 38079/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Cell Physiol
JT  - Journal of cellular physiology
JID - 0050222
RN  - 0 (Isoenzymes)
RN  - EC 6.3.2.2 (Glutamate-Cysteine Ligase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Amino Acid Sequence/genetics
MH  - Animals
MH  - Cell Physiological Phenomena
MH  - Chromosome Mapping
MH  - Disease
MH  - Gene Expression Regulation/*physiology
MH  - Glutamate-Cysteine Ligase/*genetics/metabolism
MH  - Glutathione/biosynthesis/physiology
MH  - Humans
MH  - Isoenzymes/genetics/metabolism
MH  - Molecular Sequence Data
MH  - Transcription, Genetic/physiology
RF  - 89
EDAT- 2000/01/07 00:00
MHDA- 2000/01/07 00:01
CRDT- 2000/01/07 00:00
PHST- 2000/01/07 00:00 [pubmed]
PHST- 2000/01/07 00:01 [medline]
PHST- 2000/01/07 00:00 [entrez]
AID - 10.1002/(SICI)1097-4652(200002)182:2<163::AID-JCP4>3.0.CO;2-1 [pii]
AID - 10.1002/(SICI)1097-4652(200002)182:2<163::AID-JCP4>3.0.CO;2-1 [doi]
PST - ppublish
SO  - J Cell Physiol. 2000 Feb;182(2):163-70. doi: 
      10.1002/(SICI)1097-4652(200002)182:2<163::AID-JCP4>3.0.CO;2-1.