PMID- 10626585
OWN - NLM
STAT- MEDLINE
DCOM- 20000202
LR  - 20200630
IS  - 0803-5326 (Print)
IS  - 0803-5326 (Linking)
VI  - 88
IP  - 432
DP  - 1999 Dec
TI  - Controlled trial of universal neonatal screening for early identification of 
      permanent childhood hearing impairment: coverage, positive predictive value, 
      effect on mothers and incremental yield. Wessex Universal Neonatal Screening 
      Trial Group.
PG  - 73-5
AB  - OBJECT: Congenital bilateral permanent childhood hearing impairment (PCHI) 
      impairs communication skills and, in some cases, mental health and employment 
      prospects. Management of PCHI within the first year of life can alleviate most of 
      its adverse effects. We investigated whether neonatal screening of all babies 
      born in hospital, in addition to the standard Health Visitor Distraction Test 
      (HVDT), would increase the rates of early diagnosis. METHODS: Between 1993 and 
      1996, two teams of four part-time testers and equipment moved between two pairs 
      of hospitals to achieve four periods with neonatal screening and four without 
      neonatal screening, each of 4-6 mo duration in each hospital. Babies did or did 
      not undergo neonatal screening dependent on the periods during which they were 
      born. We used a transient evoked oto-acoustic emissions (TEOAE) test followed, in 
      infants who failed this test, by an automated auditory brainstem response (AABR) 
      test on the same day. We referred babies with positive results for audiological 
      assessment. RESULTS: 53,781 infants were included in the trial, including 25,609 
      born during periods of neonatal screening. The neonatal screen achieved 87% 
      coverage of inborn births, with a false alarm rate of 1.5%, and an overall yield 
      from the screen of 90 cases of bilateral PCHI > or = 40dB HTL per 100,000 target 
      population, equivalent to 80% of the expected prevalence of the condition in the 
      population. Seventy-one more babies with moderate or severe PCHI per 100,000 
      target population were referred before age 6 mo during periods with neonatal 
      screening than during periods without. Early confirmation and management of PCHI 
      were significantly increased. The false-negative rate of neonatal screening was 
      significantly lower than that of HVDT screening (4% vs 27%). CONCLUSIONS: 
      Neonatal screening is effective in identification of congenital PCHI and may be 
      particularly useful for babies with moderate and severe PCHI for whom early 
      management may have the most benefit.
FAU - Kennedy, C R
AU  - Kennedy CR
AD  - Southampton University Hospitals Trust, UK. crk1@soton.ac.uk
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Norway
TA  - Acta Paediatr Suppl
JT  - Acta paediatrica (Oslo, Norway : 1992). Supplement
JID - 9315043
SB  - IM
MH  - Audiometry, Evoked Response
MH  - Child, Preschool
MH  - Deafness/*diagnosis/epidemiology/psychology
MH  - Evoked Potentials, Auditory, Brain Stem
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Mother-Child Relations
MH  - Neonatal Screening/*methods
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Prognosis
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - United Kingdom/epidemiology
EDAT- 2000/01/08 00:00
MHDA- 2000/01/08 00:01
CRDT- 2000/01/08 00:00
PHST- 2000/01/08 00:00 [pubmed]
PHST- 2000/01/08 00:01 [medline]
PHST- 2000/01/08 00:00 [entrez]
AID - 10.1111/j.1651-2227.1999.tb01164.x [doi]
PST - ppublish
SO  - Acta Paediatr Suppl. 1999 Dec;88(432):73-5. doi: 
      10.1111/j.1651-2227.1999.tb01164.x.