PMID- 10626739
OWN - NLM
STAT- MEDLINE
DCOM- 20000420
LR  - 20190905
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 60
IP  - 12
DP  - 1999 Dec
TI  - HLA-DRB1* and allergy to Parietaria: linkage and association analyses.
PG  - 1250-8
AB  - In this study, we used the affected sibling-pairs approach to investigate the 
      linkage of HLA (human leukocyte antigen)-DRB* with phenotypes related to allergy 
      to Parietaria, the most common pollinosis in Mediterranean countries. The study 
      population consisted of 51 nuclear families (235 subjects). Linkage was detected 
      with Parietaria skin test positivity (p < (0.01), presence of IgG and IgE 
      antibodies specific for the major allergen Par o 1 (p < 0.020 and p < 0.025, 
      respectively), and absence of Par o 1-specific IgE (p < 0.020). High levels of 
      Par o 1-specific IgG were associated with DRB1*1101 and/or DRB1*1104 (p < 0.0001 
      and p < 0.0119, respectively) in parents and probands. High levels of Par o 
      1-specific IgE were associated with DRB*1104 in parents (p < 0.017) and with 
      DRB1*1101 in probands (p < 0.0146). When siblings were categorized according to 
      high/low total IgE levels (> or =125 IU/ml and <125 IU/ml, respectively), high 
      IgE antibody response was associated with DRB1*1104 in siblings with low total 
      IgE (p < 0.034) and with DRB1*1101 in siblings with high total IgE (p < 0.05). 
      These results demonstrate that HLA-DRB1*, or genes in linkage disequilibrium, 
      contributes to susceptibility to Parietaria allergy and that total IgE levels can 
      discriminate population subsets where different alleles (at the HLA region or at 
      loci in linkage disequilibrium) contribute to control allergen-specific IgE 
      synthesis.
FAU - D'Amato, M
AU  - D'Amato M
AD  - Istituto di Biologia Cellulare, CNR, Rome, Italy.
FAU - Picardi, A
AU  - Picardi A
FAU - Menna, T
AU  - Menna T
FAU - Di Somma, C
AU  - Di Somma C
FAU - Ariano, R
AU  - Ariano R
FAU - di Pietro, A
AU  - di Pietro A
FAU - Charron, D
AU  - Charron D
FAU - Maggi, E
AU  - Maggi E
FAU - Matricardi, P
AU  - Matricardi P
FAU - Plebani, A
AU  - Plebani A
FAU - Poto, S
AU  - Poto S
FAU - Testa, G
AU  - Testa G
FAU - Sacerdoti, G
AU  - Sacerdoti G
FAU - Ruffilli, A
AU  - Ruffilli A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Allergens)
RN  - 0 (Glycoproteins)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Par o I protein, Parietaria officinalis)
RN  - 0 (Plant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Allergens/immunology
MH  - Female
MH  - *Genetic Linkage
MH  - Glycoproteins/*immunology
MH  - HLA-DR Antigens/*genetics/immunology
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Hypersensitivity/*genetics/immunology
MH  - Immunoglobulin E/immunology
MH  - Immunoglobulin G/immunology
MH  - Male
MH  - Middle Aged
MH  - *Plant Proteins
MH  - Pollen/immunology
EDAT- 2000/01/08 09:00
MHDA- 2000/04/25 09:00
CRDT- 2000/01/08 09:00
PHST- 2000/01/08 09:00 [pubmed]
PHST- 2000/04/25 09:00 [medline]
PHST- 2000/01/08 09:00 [entrez]
AID - S0198-8859(99)00112-3 [pii]
AID - 10.1016/s0198-8859(99)00112-3 [doi]
PST - ppublish
SO  - Hum Immunol. 1999 Dec;60(12):1250-8. doi: 10.1016/s0198-8859(99)00112-3.