PMID- 10627610
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 20
IP  - 1
DP  - 2000 Jan 1
TI  - Hepatocyte growth factor/scatter factor is a neurotrophic survival factor for 
      lumbar but not for other somatic motoneurons in the chick embryo.
PG  - 326-37
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is expressed in the developing 
      limb muscles of the chick embryo during the period of spinal motoneuron (MN) 
      programmed cell death, and its receptor c-met is expressed in lumbar MNs during 
      this same period. Although cultured motoneurons from brachial, thoracic, and 
      lumbar segments are all rescued from cell death by chick embryo muscle extract 
      (CMX) as well as by other specific trophic agents, HGF/SF only promotes the 
      survival of lumbar MNs. Similarly, treatment of embryos in ovo with exogenous 
      HGF/SF rescues lumbar but not other somatic MNs from cell death. Blocking 
      antibodies to HGF/SF (anti-HGF) reduce the effects of CMX on MN survival in vitro 
      and decrease the number of lumbar MNs in vivo. The expression of c-met on MNs in 
      vivo is regulated by a limb-derived trophic signal distinct from HGF/SF. HGF/SF 
      is a potent, select, and physiologically relevant survival factor for a 
      subpopulation of developing spinal MNs in the lumbar segments of the chick 
      embryo.
FAU - Novak, K D
AU  - Novak KD
AD  - Department of Neurobiology and Anatomy and the Neuroscience Program, Wake Forest 
      University School of Medicine, Winston-Salem, North Carolina 27157, USA.
FAU - Prevette, D
AU  - Prevette D
FAU - Wang, S
AU  - Wang S
FAU - Gould, T W
AU  - Gould TW
FAU - Oppenheim, R W
AU  - Oppenheim RW
LA  - eng
GR  - F32 NS010538/NS/NINDS NIH HHS/United States
GR  - R01 NS020402/NS/NINDS NIH HHS/United States
GR  - NS20402/NS/NINDS NIH HHS/United States
GR  - NS10538/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antibodies)
RN  - 0 (RNA, Messenger)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Cell Death/drug effects
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Chick Embryo
MH  - Cranial Nerves/cytology/embryology
MH  - Gene Expression Regulation, Developmental
MH  - Hepatocyte Growth Factor/antagonists & inhibitors/*genetics/*pharmacology
MH  - In Situ Hybridization
MH  - Limb Buds/embryology/innervation/physiology
MH  - Motor Neurons/chemistry/*cytology/drug effects
MH  - Proto-Oncogene Proteins c-met/analysis/biosynthesis
MH  - RNA, Messenger/analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Spinal Cord/*cytology/embryology
PMC - PMC6774126
EDAT- 2000/01/11 00:00
MHDA- 2000/01/11 00:01
PMCR- 2000/07/01
CRDT- 2000/01/11 00:00
PHST- 2000/01/11 00:00 [pubmed]
PHST- 2000/01/11 00:01 [medline]
PHST- 2000/01/11 00:00 [entrez]
PHST- 2000/07/01 00:00 [pmc-release]
AID - 3792 [pii]
AID - 10.1523/JNEUROSCI.20-01-00326.2000 [doi]
PST - ppublish
SO  - J Neurosci. 2000 Jan 1;20(1):326-37. doi: 10.1523/JNEUROSCI.20-01-00326.2000.