PMID- 10627804
OWN - NLM
STAT- MEDLINE
DCOM- 20000121
LR  - 20190705
IS  - 0007-1250 (Print)
IS  - 0007-1250 (Linking)
VI  - 175
DP  - 1999 Aug
TI  - Ecstasy--long-term effects on the human central nervous system revealed by 
      positron emission tomography.
PG  - 186-8
AB  - BACKGROUND: The main psychotropic agent of the popular illicit drug ecstasy is 
      3,4-methylenedioxymethamphetamine (MDMA). In the light of animal studies and 
      examinations of human cerebrospinal fluid, MDMA is suspected of causing 
      neurotoxic lesions to the serotonergic system. AIMS: To postulate a relationship 
      between ecstasy use and lasting alterations to the cerebral glucose metabolic 
      rate. METHOD: Positron emission tomography (PET) with 
      2-[18F]-fluoro-2-deoxy-D-glucose (FDG) was performed on seven ecstasy users and 
      seven subjects without any known history of illicit drug use. Data were compared 
      for a limited number of brain regions. RESULTS: By comparison with the control 
      group, the glucose metabolic uptake of the ecstasy user group was altered within 
      the amygdala, hippocampus and Brodmann's area II. CONCLUSIONS: The results 
      suggest the possibility that ecstasy use has lasting effects on central neuronal 
      activity in humans.
FAU - Obrocki, J
AU  - Obrocki J
AD  - Department of Psychiatry and Psychotherapy, University Hospital, Hamburg, 
      Germany.
FAU - Buchert, R
AU  - Buchert R
FAU - Vaterlein, O
AU  - Vaterlein O
FAU - Thomasius, R
AU  - Thomasius R
FAU - Beyer, W
AU  - Beyer W
FAU - Schiemann, T
AU  - Schiemann T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Psychiatry
JT  - The British journal of psychiatry : the journal of mental science
JID - 0342367
RN  - 0 (Hallucinogens)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - IY9XDZ35W2 (Glucose)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
CIN - Br J Psychiatry. 1999 Dec;175:589. PMID: 10789366
MH  - Adult
MH  - Case-Control Studies
MH  - Central Nervous System Diseases/*chemically induced/diagnostic imaging/metabolism
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Glucose/metabolism
MH  - Hallucinogens/*adverse effects
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Tomography, Emission-Computed/methods
EDAT- 2000/01/11 00:00
MHDA- 2000/01/11 00:01
CRDT- 2000/01/11 00:00
PHST- 2000/01/11 00:00 [pubmed]
PHST- 2000/01/11 00:01 [medline]
PHST- 2000/01/11 00:00 [entrez]
AID - S0007125000153450 [pii]
AID - 10.1192/bjp.175.2.186 [doi]
PST - ppublish
SO  - Br J Psychiatry. 1999 Aug;175:186-8. doi: 10.1192/bjp.175.2.186.