PMID- 10630588
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20190513
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 52
IP  - 2 Suppl
DP  - 1999 Dec
TI  - Caloric intake and aging: mechanisms in rodents and a study in nonhuman primates.
PG  - 35-40
AB  - Caloric restriction (CR) increases maximum life span in rodents while attenuating 
      the development of age-associated pathological and biological changes. Although 
      nearly all of the rodent studies have initiated CR early in life (1-3 months of 
      age), CR, when started at 12 months of age, also extends maximum life span in 
      mice. Two main questions face investigators of CR. One concerns the mechanisms by 
      which CR retards aging and diseases in rodents. There is evidence that CR may 
      act, at least in part, by reducing oxidative stress. A CR-induced decrease in 
      oxidative stress appears to be most profound in post-mitotic tissues and may 
      derive from lower mitochondrial production of free radicals. The second issue is 
      whether CR will exert similar effects in primates. Studies on CR in rhesus 
      monkeys (maximum life span approximately 40 years) support the notion of human 
      translatability. We describe the University of Wisconsin Study of rhesus monkeys 
      subjected to a 30% reduction of caloric intake starting at either 1989 or 1994 
      when they were approximately 10 years old. The data from our study and from other 
      trials suggest that CR can be safely carried out in monkeys and that certain 
      physiological effects of CR that occur in rodents (e.g., decreased blood glucose 
      and insulin levels, improved insulin sensitivity, and lowering of body 
      temperature) also occur in monkeys. Whether oxidative stress in monkeys is 
      reduced by CR will be known by the year 2000, while effects on longevity and 
      diseases should be clearly seen by, appropriately, 2020.
FAU - Wanagat, J
AU  - Wanagat J
AD  - Integrated M.D./Ph.D. Program, University of Wisconsin, Madison 53705, USA.
FAU - Allison, D B
AU  - Allison DB
FAU - Weindruch, R
AU  - Weindruch R
LA  - eng
GR  - P01 AG11915/AG/NIA NIH HHS/United States
GR  - RR00167/RR/NCRR NIH HHS/United States
GR  - T32 AG00213/AG/NIA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Energy Intake/*physiology
MH  - Humans
MH  - Longevity
MH  - Macaca mulatta
MH  - Mice
RF  - 50
EDAT- 2000/01/12 00:00
MHDA- 2000/01/12 00:01
CRDT- 2000/01/12 00:00
PHST- 2000/01/12 00:00 [pubmed]
PHST- 2000/01/12 00:01 [medline]
PHST- 2000/01/12 00:00 [entrez]
AID - 10.1093/toxsci/52.2.35 [doi]
PST - ppublish
SO  - Toxicol Sci. 1999 Dec;52(2 Suppl):35-40. doi: 10.1093/toxsci/52.2.35.