PMID- 10630590
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20190513
IS  - 1096-6080 (Print)
IS  - 1096-0929 (Linking)
VI  - 52
IP  - 2 Suppl
DP  - 1999 Dec
TI  - Influence of caloric restriction on the development of atherosclerosis in 
      nonhuman primates: progress to date.
PG  - 49-55
AB  - Caloric restriction (CR) has been observed to retard aging processes and extend 
      the maximum life span in rodents. In an effort to evaluate the effect of this 
      nutritional intervention on physiologic variables in higher species, several 
      nonhuman primate trials are ongoing. In particular, a study evaluating the 
      independent effect of CR on the extent of atherosclerosis was initiated in 1993 
      in 32 adult cynomolgus monkeys. Therefore, the trial was designed to achieve 
      identical cholesterol intake after animals were randomized to a control group or 
      a calorie-restricted group (30% reduction from baseline caloric intake). The 
      animals were routinely evaluated for glycated proteins, plasma insulin and 
      glucose levels, insulin sensitivity, and specific measures for abdominal fat 
      distribution by CT scans over a 4-year interval. The results from 4 years of 
      intervention demonstrate that CR improves cardiovascular risk factors (such as 
      visceral fat accumulation) and improves insulin sensitivity. In contrast to other 
      primate studies with normolipidemic animals, CR had no independent effects on 
      plasma lipid levels and composition in the presence of equivalent amounts of 
      dietary cholesterol intake. Preliminary analysis of atherosclerotic lesion extent 
      in the abdominal aorta has failed to demonstrate differences between control 
      animals and CR animals. Follow-up studies are being conducted to determine the 
      effect of CR on atherosclerosis extent in coronary and carotid arteries.
FAU - Cefalu, W T
AU  - Cefalu WT
AD  - Department of Medicine, University of Vermont College of Medicine, Burlington 
      05405, USA. wcefalu@zoo.uvm.edu
FAU - Wagner, J D
AU  - Wagner JD
FAU - Bell-Farrow, A D
AU  - Bell-Farrow AD
FAU - Edwards, I J
AU  - Edwards IJ
FAU - Terry, J G
AU  - Terry JG
FAU - Weindruch, R
AU  - Weindruch R
FAU - Kemnitz, J W
AU  - Kemnitz JW
LA  - eng
GR  - AG00578/AG/NIA NIH HHS/United States
GR  - AG10816/AG/NIA NIH HHS/United States
GR  - AG11915/AG/NIA NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
RN  - 0 (Cholesterol, HDL)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - Arteriosclerosis/*etiology
MH  - Body Composition
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - *Energy Intake
MH  - Female
MH  - Macaca fascicularis
MH  - Macaca mulatta
MH  - Male
MH  - Random Allocation
MH  - Risk Factors
EDAT- 2000/01/12 00:00
MHDA- 2000/01/12 00:01
CRDT- 2000/01/12 00:00
PHST- 2000/01/12 00:00 [pubmed]
PHST- 2000/01/12 00:01 [medline]
PHST- 2000/01/12 00:00 [entrez]
AID - 10.1093/toxsci/52.2.49 [doi]
PST - ppublish
SO  - Toxicol Sci. 1999 Dec;52(2 Suppl):49-55. doi: 10.1093/toxsci/52.2.49.