PMID- 10630916
OWN - NLM
STAT- MEDLINE
DCOM- 20000301
LR  - 20190501
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Print)
IS  - 0003-9888 (Linking)
VI  - 82
IP  - 1
DP  - 2000 Jan
TI  - Clinical characteristics of febrile convulsions during primary HHV-6 infection.
PG  - 62-6
AB  - OBJECTIVE: To clarify clinical characteristics of children with febrile 
      convulsions during primary human herpesvirus 6 (HHV-6) infection. SUBJECTS AND 
      METHODS: The clinical characteristics of first febrile convulsion were compared 
      between those with and without primary HHV-6 infection in 105 children. HHV-6 
      infection was verified by culture or acute/convalescent anti-HHV-6 antibody 
      titres. RESULTS: Primary infection with HHV-6 was seen in 21 of 105 patients with 
      febrile convulsions (3 upper respiratory infection, 1 lower respiratory 
      infection, and 17 exanthem subitum). 13 of 23 patients < 1 year, 19 of 79 
      patients with first febrile convulsion, and 2 of 15 with second convulsion were 
      infected with HHV-6. The median age of patients with first febrile convulsion and 
      HHV-6 was significantly lower than those without infection. The frequency of 
      clustering seizures, long lasting seizures, partial seizures, and postictal 
      paralysis was significantly higher among those with primary HHV-6 infection than 
      among those without. The frequency of atypical seizures in 19 patients with first 
      febrile convulsion associated with primary infection was significantly higher 
      than in 60 patients without primary infection. The frequency in infants younger 
      than 1 year of age was also significantly higher than that in 10 age matched 
      infants without primary infection. CONCLUSIONS: These findings suggest that 
      primary infection with HHV-6 is frequently associated with febrile convulsions in 
      infants and young children and that it often results in the development of a more 
      severe form of convulsions, such as partial seizures, prolonged seizures, and 
      repeated seizures, and might be a risk factor for subsequent development of 
      epilepsy.
FAU - Suga, S
AU  - Suga S
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, 
      Aichi 470-1192, Japan.
FAU - Suzuki, K
AU  - Suzuki K
FAU - Ihira, M
AU  - Ihira M
FAU - Yoshikawa, T
AU  - Yoshikawa T
FAU - Kajita, Y
AU  - Kajita Y
FAU - Ozaki, T
AU  - Ozaki T
FAU - Iida, K
AU  - Iida K
FAU - Saito, Y
AU  - Saito Y
FAU - Asano, Y
AU  - Asano Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
CIN - Arch Dis Child. 2000 May;82(5):428. PMID: 10836953
MH  - Age Distribution
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Herpesviridae Infections/*complications
MH  - *Herpesvirus 6, Human
MH  - Humans
MH  - Infant
MH  - Male
MH  - Risk Factors
MH  - Seizures, Febrile/*virology
PMC - PMC1718177
EDAT- 2000/01/12 09:00
MHDA- 2000/03/04 09:00
PMCR- 2003/01/01
CRDT- 2000/01/12 09:00
PHST- 2000/01/12 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/01/12 09:00 [entrez]
PHST- 2003/01/01 00:00 [pmc-release]
AID - 10.1136/adc.82.1.62 [doi]
PST - ppublish
SO  - Arch Dis Child. 2000 Jan;82(1):62-6. doi: 10.1136/adc.82.1.62.