PMID- 10631974
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20181113
IS  - 0961-8368 (Print)
IS  - 1469-896X (Electronic)
IS  - 0961-8368 (Linking)
VI  - 8
IP  - 12
DP  - 1999 Dec
TI  - The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic 
      factor/neurotrophin 4 heterodimer reveal a common Trk-binding site.
PG  - 2589-97
AB  - The neurotrophins are growth factors that are involved in the development and 
      survival of neurons. Neurotrophin release by a target tissue results in neuron 
      growth along the neurotrophin concentration gradient, culminating in the eventual 
      innervation of the target tissue. These activities are mediated through trk cell 
      surface receptors. We have determined the structures of the heterodimer formed 
      between brain-derived neurotrophic factor (BDNF) and neurotrophin 4 (NT4), as 
      well as the structure of homodimer of NT4. We also present the structure of the 
      Neurotrophin 3 homodimer, which is refined to higher resolution than previously 
      published. These structures provide the first views of the architecture of the 
      NT4 protomer. Comparison of the surface of a model of the BDNF homodimer with the 
      structures of the neurotrophin homodimers reveals common features that may be 
      important in the binding between the neurotrophins and their receptors. In 
      particular, there exists an analogous region on the surface of each neurotrophin 
      that is likely to be involved in trk receptor binding. Variations in sequence on 
      the periphery of this common region serve to confer trk receptor specificity.
FAU - Robinson, R C
AU  - Robinson RC
AD  - Structural Biology Laboratory, The Salk Institute, La Jolla, California 92037, 
      USA. bob@sbl.salk.edu
FAU - Radziejewski, C
AU  - Radziejewski C
FAU - Spraggon, G
AU  - Spraggon G
FAU - Greenwald, J
AU  - Greenwald J
FAU - Kostura, M R
AU  - Kostura MR
FAU - Burtnick, L D
AU  - Burtnick LD
FAU - Stuart, D I
AU  - Stuart DI
FAU - Choe, S
AU  - Choe S
FAU - Jones, E Y
AU  - Jones EY
LA  - eng
SI  - PDB/1B8K
SI  - PDB/1B8M
SI  - PDB/1B98
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Protein Sci
JT  - Protein science : a publication of the Protein Society
JID - 9211750
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Binding Sites
MH  - Brain-Derived Neurotrophic Factor/*chemistry
MH  - Crystallization
MH  - Crystallography, X-Ray
MH  - Humans
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*chemistry
MH  - Protein Structure, Quaternary
MH  - Receptor Protein-Tyrosine Kinases/chemistry
MH  - Receptor, Nerve Growth Factor/chemistry
PMC - PMC2144242
EDAT- 2000/01/13 09:00
MHDA- 2000/02/19 09:00
PMCR- 2000/06/01
CRDT- 2000/01/13 09:00
PHST- 2000/01/13 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/01/13 09:00 [entrez]
PHST- 2000/06/01 00:00 [pmc-release]
AID - 10.1110/ps.8.12.2589 [doi]
PST - ppublish
SO  - Protein Sci. 1999 Dec;8(12):2589-97. doi: 10.1110/ps.8.12.2589.