PMID- 10632411
OWN - NLM
STAT- MEDLINE
DCOM- 20000121
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 73
IP  - 1
DP  - 2000 Jan
TI  - Evaluation of the role of mitotic instability in karyotypically normal men with 
      oligozoospermia.
PG  - 51-5
AB  - OBJECTIVE: To estimate the incidence of sex chromosome aneuploidies in the 
      somatic cells of karyotypically normal infertile men and fertile donors. DESIGN: 
      A prospective, two-phase, controlled study. SETTING: Reproductive medicine and 
      medical genetics units of a teaching hospital. PATIENT(S): Ten patients with 
      oligozoospermia and 10 sperm donors with proved fertility, all with a normal 
      karyotype 46 XY. INTERVENTION(S): Multicolor fluorescence in situ hybridization 
      (FISH) of peripheral blood lymphocytes using a probe cocktail containing the 
      alpha satellites DXZ1 for the X centromere and DYZ1 for the heterochromatic 
      region of the long arm of the Y and the radiolabeled alpha satellite D18Z1 for 
      chromosome 18. MAIN OUTCOME MEASURE(S): The incidence of sex chromosome 
      aneuploidies in both groups. RESULT(S): A 13-fold increase in sex chromosome 
      aneuploidies was observed in the somatic cells of infertile men with 
      "unexplained" oligozoospermia compared to donors (P=.008). CONCLUSION(S): These 
      findings provide suggestive evidence for the existence of an inherent mitotic 
      instability in men with unexplained oligozoospermia.
FAU - Gazvani, M R
AU  - Gazvani MR
AD  - Department of Obstetrics and Gynaecology, Liverpool Women's Hospital, United 
      Kingdom.
FAU - Wilson, E D
AU  - Wilson ED
FAU - Richmond, D H
AU  - Richmond DH
FAU - Howard, P J
AU  - Howard PJ
FAU - Kingsland, C R
AU  - Kingsland CR
FAU - Lewis-Jones, D I
AU  - Lewis-Jones DI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - *Aneuploidy
MH  - Chromosomes, Human, Pair 18
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Karyotyping
MH  - Male
MH  - *Mitosis
MH  - Oligospermia/*genetics
MH  - Prospective Studies
MH  - *Sex Chromosomes
MH  - Tissue Donors
EDAT- 2000/01/13 00:00
MHDA- 2000/01/13 00:01
CRDT- 2000/01/13 00:00
PHST- 2000/01/13 00:00 [pubmed]
PHST- 2000/01/13 00:01 [medline]
PHST- 2000/01/13 00:00 [entrez]
AID - S0015028299004677 [pii]
AID - 10.1016/s0015-0282(99)00467-7 [doi]
PST - ppublish
SO  - Fertil Steril. 2000 Jan;73(1):51-5. doi: 10.1016/s0015-0282(99)00467-7.