PMID- 10632983
OWN - NLM
STAT- MEDLINE
DCOM- 20000307
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 51
IP  - 1
DP  - 2000 Jan
TI  - Expression of monocyte chemoattractant protein-1 in Kawasaki disease: the 
      anti-inflammatory effect of gamma globulin therapy.
PG  - 98-103
AB  - We investigated the expression of monocyte chemoattractant protein-1 (MCP-1) 
      mRNA, protein, and its bioactivity in plasma, mononuclear cells (MNC) and 
      polymorphonuclear leukocytes (PML) in patients with Kawasaki disease, including 
      those who were treated with intravenous gamma globulin. MCP-1 mRNA expression was 
      increased in the MNC and the plasma level of MCP-1 and monocyte chemotactic 
      activity in plasma in the acute phase as compared with healthy control levels and 
      decreased after the gamma globulin therapy. The infused gamma globulin contained 
      MCP-1 protein with monocyte chemotactic activity and did not show a neutralising 
      effect against MCP-1 protein in vitro. Our results suggest that the infusion of 
      gamma globulin may reduce the production of MCP-1 in MNC in patients with 
      Kawasaki disease, subsequently reducing its level in plasma. The changes in MCP-1 
      level after gamma globulin therapy may serve to alleviate the symptoms in the 
      acute phase in patients with Kawasaki disease.
FAU - Asano, T
AU  - Asano T
AD  - Department of Pediatrics, Nippon Medical School, Tokyo 113-8603, Japan.
FAU - Ogawa, S
AU  - Ogawa S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Chemokine CCL2)
RN  - 0 (RNA, Messenger)
RN  - 0 (gamma-Globulins)
SB  - IM
MH  - Acute Disease
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood/*genetics
MH  - Chemotaxis, Leukocyte
MH  - Child, Preschool
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - In Vitro Techniques
MH  - Infant
MH  - Infusions, Intravenous
MH  - Leukocytes, Mononuclear/immunology
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/genetics/*immunology/*therapy
MH  - Neutrophils/immunology
MH  - RNA, Messenger/blood/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - gamma-Globulins/administration & dosage/*therapeutic use
EDAT- 2000/01/13 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/01/13 09:00
PHST- 2000/01/13 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/01/13 09:00 [entrez]
AID - sji650 [pii]
AID - 10.1046/j.1365-3083.2000.00650.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2000 Jan;51(1):98-103. doi: 10.1046/j.1365-3083.2000.00650.x.