PMID- 10635293
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20171116
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 26
IP  - 14
DP  - 1999 Dec
TI  - [Dendritic cells and tumor specific immunity].
PG  - 2121-6
AB  - Dendritic cells (DCs) are the most efficient antigen presenting cells (APCs) that 
      initiate and modulate our internal immune responses in stimulating both B cells 
      to produce various antibodies and T cells to control cell-mediated immunity. Such 
      DCs can be classified into three groups based on their origin. One is the myeloid 
      DCs originating from CD34+ stem cells that are further differentiated into CD14+ 
      CD1a- phagocytotic, glass-adherent macrophages with the help of M-CSF, or into 
      CD14- CD1a+, Birbeck granule containing LAG-1+ Langerhans cells by GM-CSF, 
      TNF-alpha and TGF-beta 1 stimulation. The latter Langerhans cells appear to 
      differentiate into DC1 as strong stimulators of T cells displaying large amounts 
      of MHC-peptide complexes and co-stimulatory molecules, such as B7-1 and B7-2, 
      after capturing antigens and migrating to a regional lymphoid organ. The second 
      group is the lymphoid DCs originating from CD4+CD11c- cells, which differentiate 
      into DC2 when cultured with IL-3. Third is the follicular dendritic cells (FDC) 
      observed in lymphofollicules that capture foreign antigens with their Fc-receptor 
      or complement-receptors and keep the antigens inside the follicules. DC1s secrete 
      IL-12, which turns CD4 T cells into Th1 cells to induce cellular immunity, 
      whereas DC2s favor production of Th2 cells to organize humoral immunity. 
      Therefore, DCs appear to control our internal self-defense system. These unique 
      features of DCs enable us to manipulate Th1 and Th2 activation selectively, and 
      thus antigen-pulsed DCs are currently thought of as excellent tools to induce 
      specific T cell immunity towards virus-infected cells or tumor cells.
FAU - Takahashi, H
AU  - Takahashi H
AD  - Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan.
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (CD4 Antigens)
RN  - 0 (Lipopolysaccharide Receptors)
SB  - IM
MH  - Animals
MH  - CD4 Antigens/immunology
MH  - Cell Differentiation/physiology
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Killer Cells, Natural/immunology
MH  - Lipopolysaccharide Receptors/immunology
MH  - Macrophages
MH  - Mice
MH  - Neoplasms/*immunology/pathology
MH  - T-Lymphocytes/immunology
RF  - 12
EDAT- 2000/01/15 00:00
MHDA- 2000/01/15 00:01
CRDT- 2000/01/15 00:00
PHST- 2000/01/15 00:00 [pubmed]
PHST- 2000/01/15 00:01 [medline]
PHST- 2000/01/15 00:00 [entrez]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 1999 Dec;26(14):2121-6.