PMID- 10635294
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20061115
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 26
IP  - 14
DP  - 1999 Dec
TI  - [Detection of numerical aberrations in chromosomes by fluorescence in situ 
      hybridization in fine needle aspirates in the preoperative diagnosis of cancer].
PG  - 2127-30
AB  - Fine needle aspiration (FNA) samples were obtained from 176 breast tumors 
      suspected of malignancy, which were then subjected to conventional cytological 
      and fluorescence in situ hybridization (FISH) analyses using the centromeric 
      probes for chromosomes 1, 11, and 17. Histological examination revealed 157 
      breast cancers and 19 benign diseases (ten fibroadenomas, six intraductal 
      papillomas, one intracystic papilloma, and two ADH). Sensitivity, specificity, 
      and diagnostic accuracy were 85.4% 94.7%, and 86.4%, respectively, for cytology 
      and 90.4%, 100%, and 91.5%, respectively, for FISH. These results demonstrate 
      that FISH diagnosis of FNA samples has a diagnostic accuracy comparable to that 
      of conventional cytology.
FAU - Noguchi, S
AU  - Noguchi S
AD  - Department of Surgical Oncology, Osaka University Medical School, Japan.
FAU - Tsukamoto, F
AU  - Tsukamoto F
FAU - Miyoshi, Y
AU  - Miyoshi Y
FAU - Inaji, H
AU  - Inaji H
FAU - Watatani, M
AU  - Watatani M
FAU - Sasa, M
AU  - Sasa M
FAU - Inazawa, J
AU  - Inazawa J
FAU - Takami, S
AU  - Takami S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
SB  - IM
MH  - Biopsy, Needle
MH  - Breast/*pathology
MH  - Breast Neoplasms/*genetics/pathology
MH  - Chromosomes, Human, Pair 1
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 17
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Sensitivity and Specificity
EDAT- 2000/01/15 00:00
MHDA- 2000/01/15 00:01
CRDT- 2000/01/15 00:00
PHST- 2000/01/15 00:00 [pubmed]
PHST- 2000/01/15 00:01 [medline]
PHST- 2000/01/15 00:00 [entrez]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 1999 Dec;26(14):2127-30.