PMID- 10635345
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 446
IP  - 2
DP  - 1999 Dec 13
TI  - Antimutagenicity of a suberin extract from Quercus suber cork.
PG  - 225-30
AB  - The possible protective effect of a suberin extract from Quercus suber cork on 
      acridine orange (AO)-, ofloxacin- and UV radiation-induced mutagenicity 
      (bleaching activity) in Euglena gracilis was examined. To our knowledge, the 
      present results are the first attempt to analyse suberin in relation to 
      mutagenicity of some chemicals. Suberin exhibits a significant dose-dependent 
      protective effect against AO-induced mutagenicity and the concentration of 500 
      micrograms/ml completely eliminates the Euglena-bleaching activity of AO. The 
      mutagenicity of ofloxacin is also significantly reduced in the presence of 
      suberin (125, 250 and 500 micrograms/ml). However, the moderate protective effect 
      of suberin on UV radiation-induced mutagenicity was observed only at 
      concentrations 500 and 1000 micrograms/ml. Our data shows that suberin extract 
      from Q. suber cork possess antimutagenic properties and can be included in the 
      group of natural antimutagens acting in a desmutagenic manner.
FAU - Krizkova, L
AU  - Krizkova L
AD  - Institute of Cell Biology, Faculty of Science, Comenius University, Bratislava, 
      Slovak Republic. krizkova@m2.fedu.uniba.sk
FAU - Lopes, M H
AU  - Lopes MH
FAU - Polonyi, J
AU  - Polonyi J
FAU - Belicova, A
AU  - Belicova A
FAU - Dobias, J
AU  - Dobias J
FAU - Ebringer, L
AU  - Ebringer L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Antimutagenic Agents)
RN  - 0 (Lipids)
RN  - 0 (Membrane Lipids)
RN  - 0 (Mutagens)
RN  - 0 (Plant Extracts)
RN  - 11062-77-4 (Superoxides)
RN  - 8072-95-5 (suberin)
RN  - A4P49JAZ9H (Ofloxacin)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange/toxicity
MH  - Animals
MH  - Antimutagenic Agents/*pharmacology
MH  - Euglena gracilis/drug effects/genetics/radiation effects
MH  - Lipids
MH  - Membrane Lipids/*pharmacology
MH  - Mutagenicity Tests/*methods
MH  - Mutagens/toxicity
MH  - Ofloxacin/toxicity
MH  - Plant Extracts/*pharmacology
MH  - Plant Shoots/chemistry
MH  - Spectrophotometry, Ultraviolet
MH  - Superoxides/metabolism
MH  - Trees/*chemistry
MH  - Ultraviolet Rays
EDAT- 2000/01/15 00:00
MHDA- 2000/01/15 00:01
CRDT- 2000/01/15 00:00
PHST- 2000/01/15 00:00 [pubmed]
PHST- 2000/01/15 00:01 [medline]
PHST- 2000/01/15 00:00 [entrez]
AID - S1383-5718(99)00190-4 [pii]
AID - 10.1016/s1383-5718(99)00190-4 [doi]
PST - ppublish
SO  - Mutat Res. 1999 Dec 13;446(2):225-30. doi: 10.1016/s1383-5718(99)00190-4.