PMID- 10636516
OWN - NLM
STAT- MEDLINE
DCOM- 20000207
LR  - 20190818
IS  - 0029-7844 (Print)
IS  - 0029-7844 (Linking)
VI  - 95
IP  - 1
DP  - 2000 Jan
TI  - Association between DQB1 and cervical cancer in patients with human 
      papillomavirus and family controls.
PG  - 134-40
AB  - OBJECTIVE: The role of human leukocyte antigen (HLA) DQB1 alleles and human 
      papillomavirus (HPV) as contributing factors to invasive cervical cancer was 
      investigated. To overcome problems of misleading causal inferences common in 
      traditional case-control studies, a family-based test, the 
      transmission/disequilibrium test, was used. METHODS: Ninety-six patients with 
      pathologically confirmed invasive cervical cancer were ascertained. Human 
      papillomavirus types were determined in 80 patients, of whom 81.25% were 
      HPV-positive, and 18.75% were HPV-negative. Deoxyribonucleic acid was extracted 
      from samples, taken from patients and their parents, and sequenced to determine 
      DQB1 genotypes. Nuclear family data were used to test whether the DQB1 locus is 
      associated with invasive cervical cancer while controlling for high-risk 
      HPV-positive patients. The transmission/disequilibrium test evaluates whether the 
      frequency of transmission of parental marker alleles to their affected offspring 
      deviates from the expected Mendelian frequency of 50%. RESULTS: The HLA DQB1 
      locus showed evidence for allelic association with invasive cervical cancer in 
      high-risk HPV-positive patients (P = .006). The transmission/disequilibrium test 
      showed that the DQB1*0303 allele was transmitted to high-risk HPV patients more 
      often than expected by chance, chi2(1) = 8.0, P = .005 (P = .035 when correcting 
      for multiple tests). Tests of association were negative when applied to all 96 
      patients, irrespective of HPV status. No significant differences were found in 
      the distribution of the DQB1 alleles among HPV-positive patients compared with 
      those who were HPV-negative, indicating that HLA alleles are not associated with 
      susceptibility to HPV infection. CONCLUSION: These results suggest that the 
      DQB1*0303 allele increases the risk for invasive cervical cancer in women who are 
      HPV-positive.
FAU - Neuman, R J
AU  - Neuman RJ
AD  - Department of Psychiatry, Washington University School of Medicine, St. Louis, 
      Missouri, USA. roz@gretta.wustl.edu
FAU - Huettner, P C
AU  - Huettner PC
FAU - Li, L
AU  - Li L
FAU - Mardis, E R
AU  - Mardis ER
FAU - Duffy, B F
AU  - Duffy BF
FAU - Wilson, R K
AU  - Wilson RK
FAU - Rader, J S
AU  - Rader JS
LA  - eng
GR  - CA62009/CA/NCI NIH HHS/United States
GR  - MH31302/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adenocarcinoma/genetics/virology
MH  - Adult
MH  - Carcinoma, Squamous Cell/*genetics/*virology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Papillomaviridae/*isolation & purification
MH  - Papillomavirus Infections/*complications
MH  - Tumor Virus Infections/*complications
MH  - Uterine Cervical Neoplasms/*genetics/*virology
EDAT- 2000/01/15 00:00
MHDA- 2000/01/15 00:01
CRDT- 2000/01/15 00:00
PHST- 2000/01/15 00:00 [pubmed]
PHST- 2000/01/15 00:01 [medline]
PHST- 2000/01/15 00:00 [entrez]
AID - S0029-7844(99)00501-3 [pii]
AID - 10.1016/s0029-7844(99)00501-3 [doi]
PST - ppublish
SO  - Obstet Gynecol. 2000 Jan;95(1):134-40. doi: 10.1016/s0029-7844(99)00501-3.