PMID- 10637482
OWN - NLM
STAT- MEDLINE
DCOM- 20000202
LR  - 20190915
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 14
IP  - 1
DP  - 2000 Jan
TI  - Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute 
      myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients.
PG  - 93-9
AB  - The recurring translocation t(10;11)(p13;q14) which is found in acute myeloid 
      leukemia (AML) and in acute lymphoblastic leukemia (ALL) results in the fusion of 
      the putative transcription factor AF10 to CALM encoding a clathrin assembly 
      protein. Previous studies using mainly fluorescence in situ hybridization (FISH) 
      analysis have shown that the CALM/AF10 rearrangement is found in immature acute 
      myeloid leukemia (AML) of subtype M0 and M1 and in T cell ALL. In this study we 
      analyzed the CALM/AF10 and AF10/CALM fusion mRNAs in a series of three patients 
      with AML, one patient with T-ALL and two patients with precusor T lymphoblastic 
      lymphoma. In all six patients the breakpoint in CALM is at the 3' end of the 
      coding region (nt1926/1927 or nt 2091/2092). Three breakpoints could be 
      identified in AF10 (nt 588/589, nt 882/883 and nt 978/979). These data 
      demonstrate that the CALM/AF10 fusions found in patients differ only slightly 
      with respect to the portion of AF10 present and that there is no obvious 
      difference between the fusions found in AML patients compared to those found in 
      patients with lymphoid malignancies. Leukemia (2000) 14, 93-99.
FAU - Bohlander, S K
AU  - Bohlander SK
AD  - Institute of Human Genetics, Georg-August University, Gottingen, Germany.
FAU - Muschinsky, V
AU  - Muschinsky V
FAU - Schrader, K
AU  - Schrader K
FAU - Siebert, R
AU  - Siebert R
FAU - Schlegelberger, B
AU  - Schlegelberger B
FAU - Harder, L
AU  - Harder L
FAU - Schemmel, V
AU  - Schemmel V
FAU - Fonatsch, C
AU  - Fonatsch C
FAU - Ludwig, W D
AU  - Ludwig WD
FAU - Hiddemann, W
AU  - Hiddemann W
FAU - Dreyling, M H
AU  - Dreyling MH
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (AF10-CALM fusion protein, human)
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosomes, Human, Pair 10
MH  - Chromosomes, Human, Pair 11
MH  - DNA Primers
MH  - DNA, Neoplasm
MH  - *Gene Rearrangement
MH  - Humans
MH  - Leukemia, Myeloid/*genetics
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Molecular Sequence Data
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Translocation, Genetic
EDAT- 2000/01/19 00:00
MHDA- 2000/01/19 00:01
CRDT- 2000/01/19 00:00
PHST- 2000/01/19 00:00 [pubmed]
PHST- 2000/01/19 00:01 [medline]
PHST- 2000/01/19 00:00 [entrez]
AID - 10.1038/sj.leu.2401614 [doi]
PST - ppublish
SO  - Leukemia. 2000 Jan;14(1):93-9. doi: 10.1038/sj.leu.2401614.