PMID- 10637817
OWN - NLM
STAT- MEDLINE
DCOM- 20000223
LR  - 20191024
IS  - 0028-2804 (Print)
IS  - 0028-2804 (Linking)
VI  - 70
IP  - 12
DP  - 1999 Dec
TI  - [Tiagabine and non-convulsive status epilepticus].
PG  - 1104-6
AB  - A case report is given to draw attention to the risk of the occurrence of 
      nonconvulsive status epilepticus (NCSE) under the anticonvulsant tiagabine in 
      higher doses and doses increases. The patient who had no previous history of 
      status epilepticus developed several NCSE shortly after administration of 
      tiagabine. This represents strong evidence of a causal relationship. Also, in 
      experimental studies it has been shown that in higher doses a disequilibrium 
      between glial and neuronal GABA uptake may aggravate the failure of GABA 
      inhibition thus explaining this adverse side-effect.
FAU - Holtkamp, M
AU  - Holtkamp M
AD  - Neurologische Klinik und Poliklinik, Universitatsklinikum Charite, 
      Humboldt-Universitat zu Berlin.
FAU - Pfeiffer, M
AU  - Pfeiffer M
FAU - Buchheim, K
AU  - Buchheim K
FAU - Meierkord, H
AU  - Meierkord H
LA  - ger
PT  - Case Reports
PT  - Clinical Trial
PT  - Clinical Trial, Phase III
PT  - Journal Article
TT  - Tiagabin und nonkonvulsiver Status epilepticus.
PL  - Germany
TA  - Nervenarzt
JT  - Der Nervenarzt
JID - 0400773
RN  - 0 (Anticonvulsants)
RN  - 0 (Nipecotic Acids)
RN  - Z80I64HMNP (Tiagabine)
SB  - IM
MH  - Adverse Drug Reaction Reporting Systems
MH  - Aged
MH  - Alpha Rhythm/drug effects
MH  - Anticonvulsants/administration & dosage/*adverse effects
MH  - Beta Rhythm/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Therapy, Combination
MH  - Electroencephalography/drug effects
MH  - Epilepsy, Complex Partial/*drug therapy
MH  - Female
MH  - Humans
MH  - Nipecotic Acids/administration & dosage/*adverse effects
MH  - Status Epilepticus/*chemically induced/diagnosis
MH  - Tiagabine
EDAT- 2000/01/19 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/01/19 09:00
PHST- 2000/01/19 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/01/19 09:00 [entrez]
AID - 10.1007/s001150050546 [doi]
PST - ppublish
SO  - Nervenarzt. 1999 Dec;70(12):1104-6. doi: 10.1007/s001150050546.