PMID- 10639386
OWN - NLM
STAT- MEDLINE
DCOM- 20000323
LR  - 20210526
IS  - 0066-4804 (Print)
IS  - 1098-6596 (Electronic)
IS  - 0066-4804 (Linking)
VI  - 44
IP  - 2
DP  - 2000 Feb
TI  - In vitro activities of rabeprazole, a novel proton pump inhibitor, and its 
      thioether derivative alone and in combination with other antimicrobials against 
      recent clinical isolates of Helicobacter pylori.
PG  - 458-61
AB  - The MICs of rabeprazole sodium (RPZ), a newly developed benzimidazole proton pump 
      inhibitor (PPI), against 133 clinical Helicobacter pylori strains revealed a 
      higher degree of activity than the another two PPIs, lansoprazole and omeprazole. 
      Time-kill curve assays of RPZ, when combined with amoxicillin, clarithromycin, or 
      metronidazole, disclosed that synergistic effects were demonstrated in 
      combination with each antibiotic examined. Moreover, no apparent antagonistic 
      effect appeared among all of the strains tested.
FAU - Kawakami, Y
AU  - Kawakami Y
AD  - Division of Clinical Microbiology, Department of Medical Technology, School of 
      Allied Medical Sciences, Shinshu University, Matsumoto, Nagano, Japan.
FAU - Akahane, T
AU  - Akahane T
FAU - Yamaguchi, M
AU  - Yamaguchi M
FAU - Oana, K
AU  - Oana K
FAU - Takahashi, Y
AU  - Takahashi Y
FAU - Okimura, Y
AU  - Okimura Y
FAU - Okabe, T
AU  - Okabe T
FAU - Gotoh, A
AU  - Gotoh A
FAU - Katsuyama, T
AU  - Katsuyama T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Antimicrob Agents Chemother
JT  - Antimicrobial agents and chemotherapy
JID - 0315061
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Benzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 32828355LL (Rabeprazole)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Anti-Bacterial Agents/pharmacology
MH  - Anti-Ulcer Agents/*pharmacology
MH  - Benzimidazoles/chemistry/*pharmacology
MH  - Drug Interactions
MH  - Helicobacter pylori/*drug effects
MH  - Humans
MH  - Microbial Sensitivity Tests
MH  - Omeprazole/analogs & derivatives
MH  - *Proton Pump Inhibitors
MH  - Rabeprazole
PMC - PMC89707
EDAT- 2000/01/20 09:00
MHDA- 2000/03/25 09:00
PMCR- 2000/02/01
CRDT- 2000/01/20 09:00
PHST- 2000/01/20 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/01/20 09:00 [entrez]
PHST- 2000/02/01 00:00 [pmc-release]
AID - 0393 [pii]
AID - 10.1128/AAC.44.2.458-461.2000 [doi]
PST - ppublish
SO  - Antimicrob Agents Chemother. 2000 Feb;44(2):458-61. doi: 
      10.1128/AAC.44.2.458-461.2000.