PMID- 10639694
OWN - NLM
STAT- MEDLINE
DCOM- 20000211
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 147
IP  - 3
DP  - 1999 Dec
TI  - Self-administration of intravenous amphetamine: effect of nucleus accumbens CCKB 
      receptor activation on fixed-ratio responding.
PG  - 331-4
AB  - RATIONALE: The mesolimbic dopamine (DA) system is implicated in psychostimulant 
      drug self-administration. The neuropeptide cholecystokinin (CCK) is co-localised 
      with DA and inhibits nucleus accumbens (NAcc) DAergic neurotransmission via CCKB 
      receptors. OBJECTIVES: The present experiment was designed to examine the effects 
      of intra-NAcc CCKB receptor stimulation on fixed-ratio (FR) amphetamine 
      self-administration. METHODS: Wistar rats with intravenous catheters and NAcc 
      cannulae were trained to self-administer amphetamine under a FR3 schedule of 
      reinforcement. Animals performing stable self-administration were microinjected 
      with pentagastrin and assessed during 3-h sessions. RESULTS: Intra-NAcc 
      pentagastrin dose dependently increased amphetamine intake. CONCLUSIONS: These 
      results are consistent with the notion that NAcc CCKB receptor activation 
      attenuates amphetamine reward.
FAU - Bush, D E
AU  - Bush DE
AD  - Department of Psychology, University of Toronto, Ontario, Canada.
FAU - DeSousa, N J
AU  - DeSousa NJ
FAU - Vaccarino, F J
AU  - Vaccarino FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Receptor, Cholecystokinin B)
RN  - 0 (Receptors, Cholecystokinin)
RN  - EF0NX91490 (Pentagastrin)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Central Nervous System Stimulants/administration & dosage/*pharmacology
MH  - Conditioning, Operant/*drug effects
MH  - Dextroamphetamine/administration & dosage/*pharmacology
MH  - Injections
MH  - Injections, Intravenous
MH  - Male
MH  - Nucleus Accumbens/*drug effects
MH  - Pentagastrin/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Cholecystokinin B
MH  - Receptors, Cholecystokinin/*agonists
MH  - Reinforcement Schedule
MH  - Self Administration
EDAT- 2000/01/20 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/01/20 09:00
PHST- 2000/01/20 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/01/20 09:00 [entrez]
AID - 10.1007/s002130051176 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1999 Dec;147(3):331-4. doi: 10.1007/s002130051176.