PMID- 10640151
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 116
IP  - 2
DP  - 2000 Jan 15
TI  - Chronic myeloid leukemia with a rare variant Philadelphia translocation: 
      t(9;22;21)(q34;q11;q22).
PG  - 166-9
AB  - A case of chronic myeloid leukemia displaying an uncommon t(21;22)(q22;q11) is 
      reported. For the first time, this translocation has been characterized by 
      fluorescence in situ hybridization (FISH) and the reverse transcriptase 
      polymerase chain reaction (RT-PCR). FISH, with the use of whole-chromosome 
      painting probes and probes specific for the BCR and ABL genes, showed a three-way 
      variant Philadelphia translocation (9;22;21)(q34;q11;q22) with a BCR/ABL fusion 
      residing on the der(22). In addition, RT-PCR demonstrated a b2a3 BCR/ABL fusion 
      transcript. Underlying mechanisms and prognostic implications are discussed.
FAU - Guillaume, B
AU  - Guillaume B
AD  - Centre de Genetique Medicale UCL, Brussels, Belgium.
FAU - Ameye, G
AU  - Ameye G
FAU - Libouton, J M
AU  - Libouton JM
FAU - Dierlamm, J
AU  - Dierlamm J
FAU - Vaerman, J L
AU  - Vaerman JL
FAU - Straetmans, N
AU  - Straetmans N
FAU - Ferrant, A
AU  - Ferrant A
FAU - Verellen-Dumoulin, C
AU  - Verellen-Dumoulin C
FAU - Michaux, L
AU  - Michaux L
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Interferon-alpha)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
RN  - X6Q56QN5QC (Hydroxyurea)
SB  - IM
MH  - Chromosome Banding
MH  - *Chromosomes, Human, Pair 21
MH  - Female
MH  - Fusion Proteins, bcr-abl/genetics
MH  - Humans
MH  - Hydroxyurea/therapeutic use
MH  - In Situ Hybridization, Fluorescence
MH  - Interferon-alpha/therapeutic use
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy/*genetics
MH  - Middle Aged
MH  - *Philadelphia Chromosome
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2000/01/20 00:00
MHDA- 2000/01/20 00:01
CRDT- 2000/01/20 00:00
PHST- 2000/01/20 00:00 [pubmed]
PHST- 2000/01/20 00:01 [medline]
PHST- 2000/01/20 00:00 [entrez]
AID - S0165-4608(99)00115-6 [pii]
AID - 10.1016/s0165-4608(99)00115-6 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Jan 15;116(2):166-9. doi: 
      10.1016/s0165-4608(99)00115-6.