PMID- 10640178
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20190910
IS  - 0300-4864 (Print)
IS  - 0300-4864 (Linking)
VI  - 27
IP  - 3
DP  - 1998 Mar
TI  - Regenerated retinal ganglion cell axons form normal numbers of boutons but fail 
      to expand their arbors in the superior colliculus.
PG  - 187-96
AB  - Regenerated retinal ganglion cell (RGC) axons can re-form functional synapses 
      with target neurons in the superior colliculus (SC). Because preterminal axon 
      branching determines the size, shape and density of innervation fields, we 
      investigated the branching patterns and bouton formation of individual RGC axons 
      that had regrown along peripheral nerve (PN) grafts to the SC. Within the 
      superficial layers of the SC, the regenerated axons formed terminal arbors with 
      average numbers of terminal boutons that were similar to the controls. However, 
      axonal branches were shorter than normal so that the mean area of the regenerated 
      arbors was nearly one-tenth that of control arbors and the resulting fields of 
      innervation contained greater than normal numbers of synapses concentrated in 
      small areas of the target. Our results have delineated a critical defect in the 
      reconstitution of retino-collicular circuitry in adult mammals: the failure of 
      terminal RGC branches to expand appropriately. Because recent studies have 
      documented that brain-derived neurotrophic factor (BDNF) can specifically 
      lengthen RGC axonal branches not only during development in the SC but also 
      within the adult retina after axotomy, the present quantitative studies should 
      facilitate experimental attempts to correct this deficit of the regenerative 
      response.
FAU - Carter, D A
AU  - Carter DA
AD  - Centre for Research in Neuroscience, McGill University, Montreal, Quebec, Canada.
FAU - Bray, G M
AU  - Bray GM
FAU - Aguayo, A J
AU  - Aguayo AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurocytol
JT  - Journal of neurocytology
JID - 0364620
SB  - IM
MH  - Animals
MH  - Axotomy
MH  - Cricetinae
MH  - Female
MH  - Mesocricetus
MH  - Nerve Endings/*ultrastructure
MH  - Nerve Transfer
MH  - Optic Nerve Injuries/pathology
MH  - Peroneal Nerve/transplantation
MH  - *Regeneration
MH  - Retinal Ganglion Cells/*physiology/ultrastructure
MH  - Superior Colliculi/*ultrastructure
EDAT- 2000/01/20 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/01/20 09:00
PHST- 2000/01/20 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/01/20 09:00 [entrez]
AID - 10.1023/a:1006911709138 [doi]
PST - ppublish
SO  - J Neurocytol. 1998 Mar;27(3):187-96. doi: 10.1023/a:1006911709138.