PMID- 10640451
OWN - NLM
STAT- MEDLINE
DCOM- 20000301
LR  - 20221207
IS  - 0014-4800 (Print)
IS  - 0014-4800 (Linking)
VI  - 68
IP  - 1
DP  - 2000 Feb
TI  - Association of HLA-DQ and -DR alleles with protection from or infection with 
      HIV-1.
PG  - 21-8
AB  - Infection with human immunodeficiency virus type 1 (HIV-1) and progression to 
      acquired immune deficiency syndrome (AIDS) are controlled by both host genetic 
      factors and viral factors. The HLA (human leukocyte antigen) region in humans 
      controls immune response functions and tissue rejection and influences 
      susceptibility to neoplasia, autoimmune diseases, and infectious diseases 
      including HIV. Twenty-eight African American and 12 Caucasian patients 
      participated in the study. HLA-DQB1 and HLA-DRB1 genotyping was performed using 
      PCR and sequence-specific oligonucleotide probe reverse hybridization and 
      analyzed with the LiPA Key Typing System and LiPA software. DQB1*0603 was found 
      to be positively associated with HIV-1 infection and with HIV-1 infection in 
      Caucasians but not African Americans. DQB1*03032 frequencies indicate a positive 
      association with protection from HIV-1 infection. It was further found to be 
      protective against HIV-1 infection in Caucasians but not in African Amens. 
      DQB1*0201 was observed more frequently in HIV(+) African Americans than HIV(-) 
      African Americans, suggesting a positive association with HIV-1 infection in this 
      ethnic group. HLA-DRB1*04 exhibited a positive association with HIV-1 infection 
      in Caucasians. These data show that there are HLA class II alleles associated 
      with susceptibility to and protection from HIV-1 infection and that these differ 
      between ethnic groups.
CI  - Copyright 2000 Academic Press.
FAU - Roe, D L
AU  - Roe DL
AD  - Department of Pathology, University of Mississippi Medical Center, Jackson, 
      Mississippi, 39216, USA.
FAU - Lewis, R E
AU  - Lewis RE
FAU - Cruse, J M
AU  - Cruse JM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Exp Mol Pathol
JT  - Experimental and molecular pathology
JID - 0370711
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Black People/*genetics
MH  - DNA/analysis
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HIV Infections/ethnology/genetics/*prevention & control
MH  - *HIV-1
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - White People/*genetics
EDAT- 2000/01/21 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/01/21 09:00
PHST- 2000/01/21 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/01/21 09:00 [entrez]
AID - S0014-4800(99)92287-6 [pii]
AID - 10.1006/exmp.1999.2287 [doi]
PST - ppublish
SO  - Exp Mol Pathol. 2000 Feb;68(1):21-8. doi: 10.1006/exmp.1999.2287.