PMID- 10641558
OWN - NLM
STAT- MEDLINE
DCOM- 20000128
LR  - 20101118
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 29 Suppl 4
DP  - 1999 Dec
TI  - Specific IgE--one gene fits all? German Asthma Genetics Group.
PG  - 5-10
AB  - Specific immunoglobulin E (IgE) production is increased in allergic diseases. 
      Research into the main factors of IgE responsiveness are complicated by different 
      steps in the antibody production from somatic recombination to isotype switching 
      and more general amplification loops. We have therefore started a positional 
      cloning approach to identify relevant genes. Ninety-seven families, each with two 
      children with asthma, were examined. Of these, 415 persons were analysed for 13 
      specific IgE against major allergens and genotyped for 351 microsatellite markers 
      distributed in equal distances over the genome. Of the initial set of allergens, 
      four major groups were identified where the most frequent allergen was analysed 
      consecutively: birch for the tree group, mixed grass for grass pollen, 
      Dermatophagoides pteronyssinus for dust mites and cat for the pet group. Parental 
      sensitization with the same allergen seemed to be a weak risk factor for the 
      children. Also several environmental exposure variables showed only moderate 
      effects on the prevalence of IgE antibodies in children. A quantitative linkage 
      analysis of the specific IgE values gave evidence for one or two linked regions 
      but was different for each allergen. From this initial observation it is likely 
      that the factors for genetic upregulation of IgE responsiveness cannot be 
      described by the action of a single major gene. Genes seem to be more likely to 
      influence general IgE responsiveness at the amplification level rather than at 
      the level of differentiation into fine specificity of antibodies.
FAU - Wjst, M
AU  - Wjst M
AD  - Molecular Epidemiology Group, Institute of Epidemiology, GSF - National Research 
      Center for Environment and Health, Neuherberg, Germany.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - Asthma/*genetics
MH  - Cats/immunology
MH  - Child
MH  - Chromosome Mapping
MH  - Genetic Linkage
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
EDAT- 2000/01/21 00:00
MHDA- 2000/01/21 00:01
CRDT- 2000/01/21 00:00
PHST- 2000/01/21 00:00 [pubmed]
PHST- 2000/01/21 00:01 [medline]
PHST- 2000/01/21 00:00 [entrez]
PST - ppublish
SO  - Clin Exp Allergy. 1999 Dec;29 Suppl 4:5-10.