PMID- 10641563
OWN - NLM
STAT- MEDLINE
DCOM- 20000128
LR  - 20041117
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 29 Suppl 4
DP  - 1999 Dec
TI  - Genome screen and candidate gene studies in parasitized populations.
PG  - 31-4
AB  - The immunoglobulin E (IgE) antibody system is important in the genesis of asthma, 
      but it appears to have originally evolved for defence against parasite infection. 
      In order to study how IgE contributes to asthma, there are advantages in studying 
      parasitized populations. Firstly, the IgE system can be studied when it is 
      operating in a more natural state, and this could allow new insight into basic 
      immune function. Secondly, the genetic susceptibility to produce high levels of 
      IgE is more likely to be expressed, as the most intense IgE responses in nature 
      are those found in the presence of parasitic infection. These more intense IgE 
      responses should facilitate finding new 'asthma genes', assist in investigating 
      how the DNA variations in candidate genes affect gene function and provide the 
      possibility of developing new approaches to the treatment of asthma.
FAU - Lesouef, P N
AU  - Lesouef PN
AD  - Department of Paediatrics, University of Western Australia, Australia.
FAU - Goldblatt, J
AU  - Goldblatt J
FAU - Lynch, N R
AU  - Lynch NR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/genetics/immunology
MH  - *Genome, Human
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Parasitic Diseases/*genetics/*immunology
EDAT- 2000/01/21 00:00
MHDA- 2000/01/21 00:01
CRDT- 2000/01/21 00:00
PHST- 2000/01/21 00:00 [pubmed]
PHST- 2000/01/21 00:01 [medline]
PHST- 2000/01/21 00:00 [entrez]
PST - ppublish
SO  - Clin Exp Allergy. 1999 Dec;29 Suppl 4:31-4.