PMID- 10642384
OWN - NLM
STAT- MEDLINE
DCOM- 20000328
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 88
IP  - 1
DP  - 2000 Jan
TI  - Preexercise medium-chain triglyceride ingestion does not alter muscle glycogen 
      use during exercise.
PG  - 219-25
AB  - This investigation determined whether ingestion of a tolerable amount of 
      medium-chain triglycerides (MCT; approximately 25 g) reduces the rate of muscle 
      glycogen use during high-intensity exercise. On two occasions, seven well-trained 
      men cycled for 30 min at 84% maximal O(2) uptake. Exactly 1 h before exercise, 
      they ingested either 1) carbohydrate (CHO; 0.72 g sucrose/kg) or 2) MCT+CHO [0.36 
      g tricaprin (C10:0)/kg plus 0.72 g sucrose/kg]. The change in glycogen 
      concentration was measured in biopsies taken from the vastus lateralis before and 
      after exercise. Additionally, glycogen oxidation was calculated as the difference 
      between total carbohydrate oxidation and the rate of glucose disappearance from 
      plasma (R(d) glucose), as measured by stable isotope dilution techniques. The 
      change in muscle glycogen concentration was not different during MCT+CHO and CHO 
      (42.0 +/- 4.6 vs. 38.8 +/- 4.0 micromol glucosyl units/g wet wt). Furthermore, 
      calculated glycogen oxidation was also similar (331 +/- 18 vs. 329 +/- 15 
      micromol. kg(-1). min(-1)). The coingestion of MCT+CHO did increase (P < 0.05) 
      R(d) glucose at rest compared with CHO (26.9 +/- 1.5 vs. 20.7 +/- 0. 7 
      micromol.kg(-1). min(-1)), yet during exercise R(d) glucose was not different 
      during the two trials. Therefore, the addition of a small amount of MCT to a 
      preexercise CHO meal did not reduce muscle glycogen oxidation during 
      high-intensity exercise, but it did increase glucose uptake at rest.
FAU - Horowitz, J F
AU  - Horowitz JF
AD  - Department of Kinesiology and Health Education, The Human Performance Laboratory, 
      The University of Texas at Austin, Austin, Texas 78712, USA.
FAU - Mora-Rodriguez, R
AU  - Mora-Rodriguez R
FAU - Byerley, L O
AU  - Byerley LO
FAU - Coyle, E F
AU  - Coyle EF
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 9005-79-2 (Glycogen)
RN  - O1PB8EU98M (tricaprin)
RN  - PDC6A3C0OX (Glycerol)
RN  - TZP1275679 (3-Hydroxybutyric Acid)
SB  - IM
MH  - 3-Hydroxybutyric Acid/blood
MH  - Bicycling/physiology
MH  - Blood Glucose/drug effects/metabolism
MH  - Dietary Sucrose/administration & dosage/metabolism/pharmacology
MH  - Energy Metabolism/drug effects
MH  - Exercise/*physiology
MH  - Fatty Acids, Nonesterified/blood
MH  - Glycerol/blood
MH  - Glycogen/*metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Kinetics
MH  - Male
MH  - Muscle, Skeletal/drug effects/*metabolism
MH  - Oxidation-Reduction/drug effects
MH  - Oxygen Consumption/drug effects
MH  - Triglycerides/*administration & dosage/*metabolism/pharmacology
EDAT- 2000/01/21 09:00
MHDA- 2000/04/01 09:00
CRDT- 2000/01/21 09:00
PHST- 2000/01/21 09:00 [pubmed]
PHST- 2000/04/01 09:00 [medline]
PHST- 2000/01/21 09:00 [entrez]
AID - 10.1152/jappl.2000.88.1.219 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2000 Jan;88(1):219-25. doi: 10.1152/jappl.2000.88.1.219.