PMID- 10642426
OWN - NLM
STAT- MEDLINE
DCOM- 20000418
LR  - 20081121
IS  - 0741-0395 (Print)
IS  - 0741-0395 (Linking)
VI  - 18
IP  - 2
DP  - 2000 Feb
TI  - Segregation analysis of IgE levels in 335 French families (EGEA) using different 
      strategies to correct for the ascertainment through a correlated trait (asthma).
PG  - 128-42
AB  - The main objective of this study was to search for a major gene controlling total 
      serum immunoglobulin E (IgE) levels, an intermediate phenotype for asthma and 
      allergy. We studied 335 French nuclear families of the EGEA study 
      (Epidemiological study of the Genetics and Environment of Asthma), ascertained 
      through asthmatic probands (123 are parents in the family, 212 children). 
      Segregation analyses were performed by regressive models, which can take into 
      account a major gene effect, various sources of familial covariation (genetic 
      and/or environmental) as well as measured risk factors (i.e. , age, sex, smoking 
      habits). Different strategies were considered to account for the mode of 
      ascertainment of the families through a correlated trait (asthma): the 
      ascertainment mode was either ignored (strategy A) or taken into account by 
      adjusting IgE levels for the position in the family, i.e., probands, blood 
      relatives, spouses (strategy B) or excluding the asthmatic children-probands and 
      computing the likelihood of each family conditionally on parents' IgE levels 
      (strategy C). Whereas a major gene effect could not be detected with strategy A, 
      strategies B and C showed evidence for the transmission of a dominant major gene 
      for high IgE levels, which was more significant with strategy B. This gene does 
      not interact with any of the covariates and is responsible for approximately 15% 
      of IgE variation (the allele frequency is 0.65).
CI  - Copyright 2000 Wiley-Liss, Inc.
FAU - Sampogna, F
AU  - Sampogna F
AD  - INSERM U155, Paris, France.
FAU - Demenais, F
AU  - Demenais F
FAU - Hochez, J
AU  - Hochez J
FAU - Oryszczyn, M P
AU  - Oryszczyn MP
FAU - Maccario, J
AU  - Maccario J
FAU - Kauffmann, F
AU  - Kauffmann F
FAU - Feingold, J
AU  - Feingold J
FAU - Dizier, M H
AU  - Dizier MH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genet Epidemiol
JT  - Genetic epidemiology
JID - 8411723
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/*genetics
MH  - Female
MH  - Genes, Dominant
MH  - Genetic Variation
MH  - Humans
MH  - Immunoglobulin E/*analysis
MH  - Male
MH  - Risk Factors
EDAT- 2000/01/21 09:00
MHDA- 2000/04/25 09:00
CRDT- 2000/01/21 09:00
PHST- 2000/01/21 09:00 [pubmed]
PHST- 2000/04/25 09:00 [medline]
PHST- 2000/01/21 09:00 [entrez]
AID - 10.1002/(SICI)1098-2272(200002)18:2<128::AID-GEPI3>3.0.CO;2-9 [pii]
AID - 10.1002/(SICI)1098-2272(200002)18:2<128::AID-GEPI3>3.0.CO;2-9 [doi]
PST - ppublish
SO  - Genet Epidemiol. 2000 Feb;18(2):128-42. doi: 
      10.1002/(SICI)1098-2272(200002)18:2<128::AID-GEPI3>3.0.CO;2-9.