PMID- 10643677
OWN - NLM
STAT- MEDLINE
DCOM- 20000211
LR  - 20191024
VI  - 23
IP  - 12
DP  - 1999 Dec
TI  - The effect of body weight changes and endurance training on 24h substrate 
      oxidation.
PG  - 1223-32
AB  - OBJECTIVE: To investigate the effect of exercise training and dietary 
      macronutrient composition on 24 h substrate oxidation in male, obese subjects. 
      DESIGN: A 16 month exercise intervention study was executed, including a weight 
      loss period with a very low energy diet (VLED) for 2 months at the start of the 
      study. SUBJECTS: Twelve male, obese subjects (age 36.3+/-5.1 y; body weight 
      94.6+/-13.9 kg; body mass index, BMI 30.8+/-3.0 kg/m2) and in an additional study 
      15 lean, well-trained subjects (age 36.2+/-7.2 y; body weight 72.2+/-5.9 kg; BMI 
      22.3+/-1.7 kg/m2) participated. MEASUREMENTS: Substrate oxidation was measured 
      during a standardized 36 h stay in the respiration chamber at the start of the 
      study (0 months), and at 4, 10 and 16 months. In the respiration chamber subjects 
      were randomly assigned to a high-fat (Hi.F) diet (60% of energy (En%) fat) or a 
      reduced-fat (Red.F) diet (30 En% fat). The well-trained group was measured once 
      in the respiration chamber for 36 h according to the same protocol. RESULTS: At 
      any time point, independent of the diet consumed, the 24 h carbohydrate (CHO) 
      balances in the chamber were mostly negative (means ranging from +31 to -98 g/d) 
      and the fat balances mostly positive (means ranging from -26 to +38 g/d) for the 
      obese a well as for the lean, well-trained group. For both diets an increased 
      shortage of 70 g of CHO was found at 16 months compared with 4 months, and an 
      increase in fat balance of 33 g during the same time period in the obese 
      subjects, indicating that CHO oxidation had increased with 12 months endurance 
      training. In the well-trained group the 24h CHO balance was even more negative 
      for both types of diet (-103 to -185 g/d for the Red.F and Hi.F diet, 
      respectively) under similar conditions compared with the trained obese group. 
      CONCLUSION: The changes in 24 h substrate utilization in the obese, as well as in 
      the well-trained group, suggest that endurance training increased the reliance on 
      carbohydrate oxidation and therefore did not increase 24 fat oxidation.
FAU - Pasman, W J
AU  - Pasman WJ
AD  - Maastricht University, Department of Human Biology, The Netherlands. 
      Pasman@voeding.tno.nl
FAU - Westerterp, M S
AU  - Westerterp MS
FAU - Saris, W H
AU  - Saris WH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Int J Obes Relat Metab Disord
JT  - International journal of obesity and related metabolic disorders : journal of the 
      International Association for the Study of Obesity
JID - 9313169
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Adult
MH  - Body Weight/*physiology
MH  - Circadian Rhythm
MH  - *Diet, Reducing
MH  - Dietary Carbohydrates/*metabolism
MH  - Dietary Fats/*metabolism
MH  - Exercise/*physiology
MH  - Humans
MH  - Male
MH  - Obesity/*metabolism
MH  - Oxidation-Reduction
EDAT- 2000/01/22 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/01/22 09:00
PHST- 2000/01/22 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/01/22 09:00 [entrez]
AID - 10.1038/sj.ijo.0801073 [doi]
PST - ppublish
SO  - Int J Obes Relat Metab Disord. 1999 Dec;23(12):1223-32. doi: 
      10.1038/sj.ijo.0801073.