PMID- 10643807 OWN - NLM STAT- MEDLINE DCOM- 20000222 LR - 20190701 IS - 0304-3940 (Print) IS - 0304-3940 (Linking) VI - 278 IP - 1-2 DP - 2000 Jan 7 TI - Differential effect of brain-derived neurotrophic factor on high-threshold mechanosensitivity in a rat neuropathic pain model. PG - 85-8 AB - We investigated the effect of the systemic infusion of brain derived neurotrophic factor (BDNF) on the behavioral response in a rat neuropathic pain model. One microgram per hour infusion of BDNF significantly attenuated mechanical hyperalgesia tested by the pin-prick test, however, 20 microg/h-BDNF infusion, on the contrary, enhanced the response. Neither 0.5 nor 10 microg/h-BDNF infusion influenced the mechanical hyperalgesia. Mechanical allodynia and thermal hyperalgesia, tested using a von Frey filament (23.0 mN) and the plantar test, were not influenced by BDNF treatment. These data suggest that systemic BDNF treatment can specifically alter high-threshold mechanosensitivity. FAU - Miki, K AU - Miki K AD - Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. FAU - Fukuoka, T AU - Fukuoka T FAU - Tokunaga, A AU - Tokunaga A FAU - Kondo, E AU - Kondo E FAU - Dai, Y AU - Dai Y FAU - Noguchi, K AU - Noguchi K LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Recombinant Proteins) SB - IM MH - Animals MH - Brain-Derived Neurotrophic Factor/administration & dosage/*pharmacology/therapeutic use MH - Denervation MH - Hot Temperature MH - Hyperalgesia/drug therapy/etiology/*physiopathology MH - Infusions, Parenteral MH - Male MH - Mechanoreceptors/*drug effects MH - Neuralgia/drug therapy/etiology/*physiopathology MH - Pain MH - Rats MH - Rats, Sprague-Dawley MH - Recombinant Proteins/pharmacology/therapeutic use MH - Sensory Thresholds/*drug effects MH - Spinal Nerves/injuries MH - *Stress, Mechanical EDAT- 2000/01/22 09:00 MHDA- 2000/02/26 09:00 CRDT- 2000/01/22 09:00 PHST- 2000/01/22 09:00 [pubmed] PHST- 2000/02/26 09:00 [medline] PHST- 2000/01/22 09:00 [entrez] AID - S0304-3940(99)00908-8 [pii] AID - 10.1016/s0304-3940(99)00908-8 [doi] PST - ppublish SO - Neurosci Lett. 2000 Jan 7;278(1-2):85-8. doi: 10.1016/s0304-3940(99)00908-8.