PMID- 10644611
OWN - NLM
STAT- MEDLINE
DCOM- 20000607
LR  - 20200930
IS  - 0363-6135 (Print)
IS  - 0363-6135 (Linking)
VI  - 278
IP  - 1
DP  - 2000 Jan
TI  - Estrogen status affects sensitivity to focal cerebral ischemia in stroke-prone 
      spontaneously hypertensive rats.
PG  - H290-4
AB  - Estrogen treatment has been shown to reduce ischemic brain damage. Because 
      endogenous estrogen levels fluctuate markedly during the estrous cycle, we 
      investigated the effect of stage of estrous cycle on ischemic brain damage. 
      Halothane anesthetized 3- to 5-mo-old female Wistar-Kyoto rats (WKY) and 
      stroke-prone spontaneously hypertensive rats (SHRSP) in proestrus (high estradiol 
      levels) or metestrus (low estradiol levels) underwent permanent middle cerebral 
      artery occlusion. In SHRSP, infarct volume at 24 h postocclusion was 24% smaller 
      in proestrus compared with metestrus [208.6 +/- 9.5 mm(3) (n = 7) vs. 272.7 +/- 
      23.8 mm(3) (n = 7), respectively, means +/- SE; P = 0.0278, unpaired t-test]. In 
      WKY, infarct volumes were similar in proestrus and metestrus [157.0 +/- 5.4 mm(3) 
      (n = 5) and 131.5 +/- 16.5 mm(3) (n = 8), respectively; P = not significant 
      (NS)]. Brain swelling (ipsilateral minus contralateral hemispheric volumes) was 
      similar in proestrus and metestrus for SHRSP [138 +/- 9 mm(3) (n = 6) and 136 +/- 
      10 mm(3) (n = 7), respectively] and for WKY [103 +/- 15 mm(3) (n = 5) and 90 +/- 
      11 mm(3) (n = 8), respectively]. Thus the reduction in infarct size in SHRSP is 
      caused by a true attenuation of the infarct volume and not simply by a reduction 
      in brain edema.
FAU - Carswell, H V
AU  - Carswell HV
AD  - Wellcome Surgical Institute, University of Glasgow, Glasgow G61 1QH, United 
      Kingdom. hvo1a@udcf.gla.ac.uk
FAU - Dominiczak, A F
AU  - Dominiczak AF
FAU - Macrae, I M
AU  - Macrae IM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
RN  - 0 (Estrogens)
SB  - IM
MH  - Animals
MH  - Brain Edema/etiology
MH  - Brain Ischemia/*etiology/pathology
MH  - Disease Susceptibility
MH  - Estrogens/*blood
MH  - Female
MH  - Hypertension/*complications
MH  - Metestrus
MH  - Proestrus
MH  - Rats
MH  - Rats, Inbred SHR/*physiology
MH  - Rats, Inbred WKY
MH  - Stroke/*etiology
EDAT- 2000/01/25 09:00
MHDA- 2000/06/10 09:00
CRDT- 2000/01/25 09:00
PHST- 2000/01/25 09:00 [pubmed]
PHST- 2000/06/10 09:00 [medline]
PHST- 2000/01/25 09:00 [entrez]
AID - 10.1152/ajpheart.2000.278.1.H290 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2000 Jan;278(1):H290-4. doi: 
      10.1152/ajpheart.2000.278.1.H290.