PMID- 10646908
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20181130
IS  - 0007-0920 (Print)
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Linking)
VI  - 82
IP  - 2
DP  - 2000 Jan
TI  - Anti-tumour activity of tachykinin NK1 receptor antagonists on human glioma U373 
      MG xenograft.
PG  - 480-7
AB  - Astrocytes harbour functional receptors to many neurotransmitters, including 
      substance P (SP), an undecapeptide belonging to the tachykinin family of peptide 
      transmitters. SP activates malignant glial cells to induce cytokine release and 
      proliferation, both responses being relevant for tumour progression. In tumours 
      developed in nude mice transplanted subcutaneously (s.c.) to U373 MG human glioma 
      cells, the presence of SP was observed at immunohistochemistry. Although the 
      administration of exogenous SP did not significantly affect the size or 
      development of U373 MG xenograft, a role of SP in supporting glioma progression 
      in vivo was highlighted by the tumour growth inhibition induced by highly 
      specific and selective human tachykinin NK1 receptor antagonists (MEN 11467 and 
      MEN 11149). The anti-tumour activity of MEN 11467 was observed both with s.c. or 
      intravenous treatments and was partially reverted by the concomitant 
      administration of exogenous SP. Doxorubicin did not show any activity in 
      controlling U373 MG growth in this in vivo model. A novel therapeutic approach to 
      treat malignant gliomas with tachykinin NK1 receptor antagonists is suggested by 
      these findings.
FAU - Palma, C
AU  - Palma C
AD  - Menarini Ricerche S.p.A., Department of Pharmacology, Pomezia, RM, Italy.
FAU - Bigioni, M
AU  - Bigioni M
FAU - Irrissuto, C
AU  - Irrissuto C
FAU - Nardelli, F
AU  - Nardelli F
FAU - Maggi, C A
AU  - Maggi CA
FAU - Manzini, S
AU  - Manzini S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (Cyclohexylamines)
RN  - 0 (Cytokines)
RN  - 0 (Indoles)
RN  - 0 (MEN 11149)
RN  - 0 (MEN 11467)
RN  - 0 (Naphthalenes)
RN  - 0 (Receptors, Tachykinin)
RN  - 0 (Tachykinins)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Animals
MH  - Cell Division
MH  - Cyclohexylamines/pharmacology
MH  - Cytokines/metabolism
MH  - Disease Progression
MH  - Glioma/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Indoles/pharmacology
MH  - Mice
MH  - Mice, Nude
MH  - Naphthalenes/pharmacology
MH  - Receptors, Tachykinin/*antagonists & inhibitors
MH  - Substance P/pharmacology
MH  - Tachykinins/*pharmacology
MH  - Transplantation, Heterologous
PMC - PMC2363296
EDAT- 2000/01/26 00:00
MHDA- 2000/01/26 00:01
PMCR- 2001/01/18
CRDT- 2000/01/26 00:00
PHST- 2000/01/26 00:00 [pubmed]
PHST- 2000/01/26 00:01 [medline]
PHST- 2000/01/26 00:00 [entrez]
PHST- 2001/01/18 00:00 [pmc-release]
AID - S0007092099909461 [pii]
AID - 10.1054/bjoc.1999.0946 [doi]
PST - ppublish
SO  - Br J Cancer. 2000 Jan;82(2):480-7. doi: 10.1054/bjoc.1999.0946.