PMID- 10647076
OWN - NLM
STAT- MEDLINE
DCOM- 20000202
LR  - 20221207
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 49
IP  - 1
DP  - 2000 Jan
TI  - Intermittent administration of brain-derived neurotrophic factor ameliorates 
      glucose metabolism in obese diabetic mice.
PG  - 129-33
AB  - We have previously shown that brain-derived neurotrophic factor (BDNF), a member 
      of the neurotrophin family, interacts with the endocrine system in obese diabetic 
      mice, and systemic peripheral administration of BDNF regulates glucose metabolism 
      in this model. Results from the present study show that the hypoglycemic effect 
      induced by 2 weeks' daily administration of BDNF (20 mg/kg/d) to db/db mice lasts 
      for several weeks after treatment cessation, irrespective of food reduction. On 
      the other hand, the antidiabetic agent, metformin had no lasting effect. This 
      duration of the BDNF hypoglycemic action prompted us to examine the efficacy of 
      BDNF intermittent administration on glucose metabolism. BDNF administered once or 
      twice per week (70 mg/kg/wk) to db/db mice for 3 weeks significantly reduced 
      blood glucose concentrations and hemoglobin A(1c), (HbA(1c)) as compared with ad 
      libitum-fed phosphate-buffered saline (PBS)-treated and pair-fed PBS-treated 
      groups. This suggests that BDNF not only temporarily reduced blood glucose 
      concentrations but also ameliorated systemic glucose balance in this obese 
      diabetic mouse model during the experimental period. Our results indicate that 
      BDNF could be a novel hypoglycemic agent with an exceptional ability to normalize 
      glucose metabolism even with treatment as infrequently as once per week.
FAU - Ono, M
AU  - Ono M
AD  - Discovery Laboratories II, Sumitomo Pharmaceuticals Research Center, Osaka, 
      Japan.
FAU - Itakura, Y
AU  - Itakura Y
FAU - Nonomura, T
AU  - Nonomura T
FAU - Nakagawa, T
AU  - Nakagawa T
FAU - Nakayama, C
AU  - Nakayama C
FAU - Taiji, M
AU  - Taiji M
FAU - Noguchi, H
AU  - Noguchi H
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Body Weight/drug effects
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Diabetes Mellitus/blood/drug therapy
MH  - Diabetes Mellitus, Type 2/blood/drug therapy
MH  - Eating/drug effects
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/*pharmacology
MH  - Mice
MH  - Mice, Obese
MH  - Obesity
MH  - Time Factors
EDAT- 2000/01/26 00:00
MHDA- 2000/01/26 00:01
CRDT- 2000/01/26 00:00
PHST- 2000/01/26 00:00 [pubmed]
PHST- 2000/01/26 00:01 [medline]
PHST- 2000/01/26 00:00 [entrez]
AID - S0026-0495(00)90988-0 [pii]
AID - 10.1016/s0026-0495(00)90988-0 [doi]
PST - ppublish
SO  - Metabolism. 2000 Jan;49(1):129-33. doi: 10.1016/s0026-0495(00)90988-0.