PMID- 10648416
OWN - NLM
STAT- MEDLINE
DCOM- 20000224
LR  - 20220318
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 95
IP  - 3
DP  - 2000 Feb 1
TI  - A primitive hematopoietic cell is the target for the leukemic transformation in 
      human philadelphia-positive acute lymphoblastic leukemia.
PG  - 1007-13
AB  - BCR-ABL is a chimeric oncogene generated by translocation of sequences from the 
      chromosomal counterpart (c-ABL gene) on chromosome 9 into the BCR gene on 
      chromosome 22. Alternative chimeric proteins, BCR-ABL(p190) and BCR-ABL(p210), 
      are produced that are characteristic of chronic myelogenous leukemia (CML) and 
      Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph(1)-ALL). In 
      CML, the transformation occurs at the level of pluripotent stem cells. However, 
      Ph(1)-ALL is thought to affect progenitor cells with lymphoid differentiation. 
      Here we demonstrate that the cell capable of initiating human Ph(1)-ALL in 
      non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID), 
      termed SCID leukemia-initiating cell (SL-IC), possesses the differentiative and 
      proliferative capacities and the potential for self-renewal expected of a 
      leukemic stem cell. The SL-ICs from all Ph(1)-ALL analyzed, regardless of the 
      heterogeneity in maturation characteristics of the leukemic blasts, were 
      exclusively CD34(+ )CD38(-), which is similar to the cell-surface phenotype of 
      normal SCID-repopulating cells. This indicates that normal primitive cells, 
      rather than committed progenitor cells, are the target for leukemic 
      transformation in Ph(1)-ALL.
FAU - Cobaleda, C
AU  - Cobaleda C
AD  - Departamento de Proliferacion y Diferenciacion Celular, Instituto de 
      Microbiologia Bioquimica, Universidad de Salamanca, Salamanca, Spain.
FAU - Gutierrez-Cianca, N
AU  - Gutierrez-Cianca N
FAU - Perez-Losada, J
AU  - Perez-Losada J
FAU - Flores, T
AU  - Flores T
FAU - Garcia-Sanz, R
AU  - Garcia-Sanz R
FAU - Gonzalez, M
AU  - Gonzalez M
FAU - Sanchez-Garcia, I
AU  - Sanchez-Garcia I
LA  - eng
GR  - 1 R01 CA79955-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD34)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
RN  - EC 3.2.2.5 (ADP-ribosyl Cyclase)
RN  - EC 3.2.2.5 (CD38 protein, human)
RN  - EC 3.2.2.5 (Cd38 protein, mouse)
RN  - EC 3.2.2.5 (NAD+ Nucleosidase)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
CIN - Blood. 2000 Apr 1;95(7):2211. PMID: 10787238
MH  - ADP-ribosyl Cyclase
MH  - ADP-ribosyl Cyclase 1
MH  - Animals
MH  - Antigens, CD/analysis
MH  - Antigens, CD34/analysis
MH  - Antigens, Differentiation/analysis
MH  - Antigens, Neoplasm/analysis
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cell Transformation, Neoplastic/*pathology
MH  - Fusion Proteins, bcr-abl/physiology
MH  - Hematopoietic Stem Cells/classification/*pathology
MH  - Humans
MH  - Immunophenotyping
MH  - Membrane Glycoproteins
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, SCID
MH  - NAD+ Nucleosidase/analysis
MH  - Neoplasm Transplantation
MH  - Neoplastic Stem Cells/classification/*pathology/transplantation
MH  - Philadelphia Chromosome
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology
EDAT- 2000/01/29 09:00
MHDA- 2000/04/29 09:00
CRDT- 2000/01/29 09:00
PHST- 2000/01/29 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/01/29 09:00 [entrez]
AID - S0006-4971(20)67179-8 [pii]
PST - ppublish
SO  - Blood. 2000 Feb 1;95(3):1007-13.